Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins; Amanda Dobbyn; Douglas M. Ruderfer; Gabriel Hoffman; Weiqing Wang; Antonio F. Pardinas; Veera M. Rajagopal; Thomas D. Als; Hoang T. Nguyen; Kiran Girdhar; James Boocock; Panos Roussos; Menachem Fromer; Robin Kramer; Enrico Domenici; Eric R. Gamazon; Shaun Purcell; Ditte Demontis; Anders D. Borglum; James T. R. Walters; Michael C. O'Donovan; Patrick Sullivan; Michael J. Owen; Bernie Devlin; Solveig K. Sieberts; Nancy J. Cox; Hae Kyung Im; Pamela Sklar; Eli A. Stahl; Jessica S. Johnson; Hardik R. Shah; Lambertus L. Klein; Kristen K. Dang; Benjamin A. Logsdon; Milind C. Mahajan; Lara M. Mangravite; Hiroyoshi Toyoshiba; Raquel E. Gur; Chang-Gyu Hahn; Eric Schadt; David A. Lewis; Vahram Haroutunian; Mette A. Peters; Barbara K. Lipska; Joseph D. Buxbaum; Keisuke Hirai; Thanneer M. Perumal; Richard Bruggeman; Inez Myin-Germeys; Jim Van Os; CommonMind Consortium; Psychiat Genomics Consortium; iPSYCH-GEMS Schizophrenia Working

doi:10.1038/s41588-019-0364-4

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins^*, Amanda Dobbyn, Douglas M. Ruderfer, Gabriel Hoffman, Weiqing Wang, Antonio F. Pardinas, Veera M. Rajagopal, Thomas D. Als, Hoang T. Nguyen, Kiran Girdhar, James Boocock, Panos Roussos, Menachem Fromer, Robin Kramer, Enrico Domenici, Eric R. Gamazon, Shaun Purcell, Ditte Demontis, Anders D. Borglum, James T. R. WaltersMichael C. O'Donovan, Patrick Sullivan, Michael J. Owen, Bernie Devlin, Solveig K. Sieberts, Nancy J. Cox, Hae Kyung Im, Pamela Sklar, Eli A. Stahl, Jessica S. Johnson, Hardik R. Shah, Lambertus L. Klein, Kristen K. Dang, Benjamin A. Logsdon, Milind C. Mahajan, Lara M. Mangravite, Hiroyoshi Toyoshiba, Raquel E. Gur, Chang-Gyu Hahn, Eric Schadt, David A. Lewis, Vahram Haroutunian, Mette A. Peters, Barbara K. Lipska, Joseph D. Buxbaum, Keisuke Hirai, Thanneer M. Perumal, Richard Bruggeman, Inez Myin-Germeys, Jim Van Os, CommonMind Consortium, Psychiat Genomics Consortium, iPSYCH-GEMS Schizophrenia Working

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	659-+
Number of pages	18
Journal	Nature Genetics
Volume	51
Issue number	4
DOIs	https://doi.org/10.1038/s41588-019-0364-4
Publication status	Published - Apr 2019

Keywords

ACUTE INTERMITTENT PORPHYRIA
COGNITIVE DEFICITS
ASSOCIATION
MOUSE
TRANSCRIPTOME
CHILDHOOD
TRAITS
PSYCHOSIS
DISORDER
VARIANTS

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10.1038/s41588-019-0364-4

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Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardinas, A. F., Rajagopal, V. M., Als, T. D., Nguyen, H. T., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Domenici, E., Gamazon, E. R., Purcell, S., Demontis, D., Borglum, A. D., ... iPSYCH-GEMS Schizophrenia Working (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51(4), 659-+. https://doi.org/10.1038/s41588-019-0364-4

Huckins, Laura M. ; Dobbyn, Amanda ; Ruderfer, Douglas M. ; Hoffman, Gabriel ; Wang, Weiqing ; Pardinas, Antonio F. ; Rajagopal, Veera M. ; Als, Thomas D. ; Nguyen, Hoang T. ; Girdhar, Kiran ; Boocock, James ; Roussos, Panos ; Fromer, Menachem ; Kramer, Robin ; Domenici, Enrico ; Gamazon, Eric R. ; Purcell, Shaun ; Demontis, Ditte ; Borglum, Anders D. ; Walters, James T. R. ; O'Donovan, Michael C. ; Sullivan, Patrick ; Owen, Michael J. ; Devlin, Bernie ; Sieberts, Solveig K. ; Cox, Nancy J. ; Im, Hae Kyung ; Sklar, Pamela ; Stahl, Eli A. ; Johnson, Jessica S. ; Shah, Hardik R. ; Klein, Lambertus L. ; Dang, Kristen K. ; Logsdon, Benjamin A. ; Mahajan, Milind C. ; Mangravite, Lara M. ; Toyoshiba, Hiroyoshi ; Gur, Raquel E. ; Hahn, Chang-Gyu ; Schadt, Eric ; Lewis, David A. ; Haroutunian, Vahram ; Peters, Mette A. ; Lipska, Barbara K. ; Buxbaum, Joseph D. ; Hirai, Keisuke ; Perumal, Thanneer M. ; Bruggeman, Richard ; Myin-Germeys, Inez ; Van Os, Jim ; CommonMind Consortium ; Psychiat Genomics Consortium ; iPSYCH-GEMS Schizophrenia Working. / Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. In: Nature Genetics. 2019 ; Vol. 51, No. 4. pp. 659-+.

@article{890e1e270c1043e1bde31a26d8661101,

title = "Gene expression imputation across multiple brain regions provides insights into schizophrenia risk",

keywords = "ACUTE INTERMITTENT PORPHYRIA, COGNITIVE DEFICITS, ASSOCIATION, MOUSE, TRANSCRIPTOME, CHILDHOOD, TRAITS, PSYCHOSIS, DISORDER, VARIANTS",

author = "Huckins, {Laura M.} and Amanda Dobbyn and Ruderfer, {Douglas M.} and Gabriel Hoffman and Weiqing Wang and Pardinas, {Antonio F.} and Rajagopal, {Veera M.} and Als, {Thomas D.} and Nguyen, {Hoang T.} and Kiran Girdhar and James Boocock and Panos Roussos and Menachem Fromer and Robin Kramer and Enrico Domenici and Gamazon, {Eric R.} and Shaun Purcell and Ditte Demontis and Borglum, {Anders D.} and Walters, {James T. R.} and O'Donovan, {Michael C.} and Patrick Sullivan and Owen, {Michael J.} and Bernie Devlin and Sieberts, {Solveig K.} and Cox, {Nancy J.} and Im, {Hae Kyung} and Pamela Sklar and Stahl, {Eli A.} and Johnson, {Jessica S.} and Shah, {Hardik R.} and Klein, {Lambertus L.} and Dang, {Kristen K.} and Logsdon, {Benjamin A.} and Mahajan, {Milind C.} and Mangravite, {Lara M.} and Hiroyoshi Toyoshiba and Gur, {Raquel E.} and Chang-Gyu Hahn and Eric Schadt and Lewis, {David A.} and Vahram Haroutunian and Peters, {Mette A.} and Lipska, {Barbara K.} and Buxbaum, {Joseph D.} and Keisuke Hirai and Perumal, {Thanneer M.} and Richard Bruggeman and Inez Myin-Germeys and {Van Os}, Jim and {CommonMind Consortium} and {Psychiat Genomics Consortium} and {iPSYCH-GEMS Schizophrenia Working}",

year = "2019",

month = apr,

doi = "10.1038/s41588-019-0364-4",

language = "English",

volume = "51",

pages = "659--+",

journal = "Nature Genetics",

issn = "1061-4036",

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Huckins, LM, Dobbyn, A, Ruderfer, DM, Hoffman, G, Wang, W, Pardinas, AF, Rajagopal, VM, Als, TD, Nguyen, HT, Girdhar, K, Boocock, J, Roussos, P, Fromer, M, Kramer, R, Domenici, E, Gamazon, ER, Purcell, S, Demontis, D, Borglum, AD, Walters, JTR, O'Donovan, MC, Sullivan, P, Owen, MJ, Devlin, B, Sieberts, SK, Cox, NJ, Im, HK, Sklar, P, Stahl, EA, Johnson, JS, Shah, HR, Klein, LL, Dang, KK, Logsdon, BA, Mahajan, MC, Mangravite, LM, Toyoshiba, H, Gur, RE, Hahn, C-G, Schadt, E, Lewis, DA, Haroutunian, V, Peters, MA, Lipska, BK, Buxbaum, JD, Hirai, K, Perumal, TM, Bruggeman, R, Myin-Germeys, I, Van Os, J, CommonMind Consortium, Psychiat Genomics Consortium & iPSYCH-GEMS Schizophrenia Working 2019, 'Gene expression imputation across multiple brain regions provides insights into schizophrenia risk', Nature Genetics, vol. 51, no. 4, pp. 659-+. https://doi.org/10.1038/s41588-019-0364-4

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. / Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing; Pardinas, Antonio F.; Rajagopal, Veera M.; Als, Thomas D.; Nguyen, Hoang T.; Girdhar, Kiran; Boocock, James; Roussos, Panos; Fromer, Menachem; Kramer, Robin; Domenici, Enrico; Gamazon, Eric R.; Purcell, Shaun; Demontis, Ditte; Borglum, Anders D.; Walters, James T. R.; O'Donovan, Michael C.; Sullivan, Patrick; Owen, Michael J.; Devlin, Bernie; Sieberts, Solveig K.; Cox, Nancy J.; Im, Hae Kyung; Sklar, Pamela; Stahl, Eli A.; Johnson, Jessica S.; Shah, Hardik R.; Klein, Lambertus L.; Dang, Kristen K.; Logsdon, Benjamin A.; Mahajan, Milind C.; Mangravite, Lara M.; Toyoshiba, Hiroyoshi; Gur, Raquel E.; Hahn, Chang-Gyu; Schadt, Eric; Lewis, David A.; Haroutunian, Vahram; Peters, Mette A.; Lipska, Barbara K.; Buxbaum, Joseph D.; Hirai, Keisuke; Perumal, Thanneer M.; Bruggeman, Richard; Myin-Germeys, Inez; Van Os, Jim; CommonMind Consortium; Psychiat Genomics Consortium; iPSYCH-GEMS Schizophrenia Working.

In: Nature Genetics, Vol. 51, No. 4, 04.2019, p. 659-+.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Huckins, Laura M.

AU - Dobbyn, Amanda

AU - Ruderfer, Douglas M.

AU - Hoffman, Gabriel

AU - Wang, Weiqing

AU - Pardinas, Antonio F.

AU - Rajagopal, Veera M.

AU - Als, Thomas D.

AU - Nguyen, Hoang T.

AU - Girdhar, Kiran

AU - Boocock, James

AU - Roussos, Panos

AU - Fromer, Menachem

AU - Kramer, Robin

AU - Domenici, Enrico

AU - Gamazon, Eric R.

AU - Purcell, Shaun

AU - Demontis, Ditte

AU - Borglum, Anders D.

AU - Walters, James T. R.

AU - O'Donovan, Michael C.

AU - Sullivan, Patrick

AU - Owen, Michael J.

AU - Devlin, Bernie

AU - Sieberts, Solveig K.

AU - Cox, Nancy J.

AU - Im, Hae Kyung

AU - Sklar, Pamela

AU - Stahl, Eli A.

AU - Johnson, Jessica S.

AU - Shah, Hardik R.

AU - Klein, Lambertus L.

AU - Dang, Kristen K.

AU - Logsdon, Benjamin A.

AU - Mahajan, Milind C.

AU - Mangravite, Lara M.

AU - Toyoshiba, Hiroyoshi

AU - Gur, Raquel E.

AU - Hahn, Chang-Gyu

AU - Schadt, Eric

AU - Lewis, David A.

AU - Haroutunian, Vahram

AU - Peters, Mette A.

AU - Lipska, Barbara K.

AU - Buxbaum, Joseph D.

AU - Hirai, Keisuke

AU - Perumal, Thanneer M.

AU - Bruggeman, Richard

AU - Myin-Germeys, Inez

AU - Van Os, Jim

AU - CommonMind Consortium

AU - Psychiat Genomics Consortium

AU - iPSYCH-GEMS Schizophrenia Working

PY - 2019/4

Y1 - 2019/4

KW - ACUTE INTERMITTENT PORPHYRIA

KW - COGNITIVE DEFICITS

KW - ASSOCIATION

KW - MOUSE

KW - TRANSCRIPTOME

KW - CHILDHOOD

KW - TRAITS

KW - PSYCHOSIS

KW - DISORDER

KW - VARIANTS

U2 - 10.1038/s41588-019-0364-4

DO - 10.1038/s41588-019-0364-4

M3 - Article

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VL - 51

SP - 659-+

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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ER -