Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms

Evelien Van Assche*, Tim Moons, Ozan Cinar, Wolfgang Viechtbauer, Albertine J. Oldehinkel, Karla Van Leeuwen, Karine Verschueren, Hilde Colpin, Diether Lambrechts, Wim Van den Noortgate, Luc Goossens, Stephan Claes, Ruud van Winkel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: Most gene-environment interaction studies (GxE) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that accounts for the polygenic nature of most psychiatric phenotypes and reduces the risk of false-positive findings. We apply this method focusing on the role of perceived parental support, psychological control, and harsh punishment in depressive symptoms in adolescence. Methods: Analyses were conducted on 982 adolescents of Caucasian origin (M-age (SD)=13.78 (.94) years) genotyped for 4,947 SNPs in 263 genes, selected based on a literature survey. The Leuven Adolescent Perceived Parenting Scale (LAPPS) and the Parental Behavior Scale (PBS) were used to assess perceived parental psychological control, harsh punishment, and support. The Center for Epidemiologic Studies Depression Scale (CES-D) was the outcome. We used gene-based testing taking into account linkage disequilibrium to identify genes containing SNPs exhibiting an interaction with environmental factors yielding a p-value per single gene. Significant results at the corrected p-value of p

Original languageEnglish
Pages (from-to)1301-1309
Number of pages9
JournalJournal of Child Psychology and Psychiatry
Volume58
Issue number12
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Gene-environment interaction
  • polygenic
  • parenting
  • gene-based testing
  • adolescents
  • depression
  • GENOME-WIDE ASSOCIATION
  • MAJOR DEPRESSION
  • ENVIRONMENT INTERACTIONS
  • SEROTONIN TRANSPORTER
  • MISSING HERITABILITY
  • CHILDHOOD DEPRESSION
  • RECEPTORS
  • CHILDREN
  • RISK
  • LOCI

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