Gene analysis for studying the process of weight regain after weight loss

Research output: ThesisDoctoral ThesisInternal

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It is so frustrating to finally lose some weight only to gain it back almost immediately. Research conducted at Maastricht University provides new insight into the way this yo-yo effect works. When we lose weight, our fat cells lose some of the fat they have stored. As a result, the cytoskeleton does not match the cell volume anymore. That is why the fat cells will develop stress. A fat cell can lose stress by hormonally stimulating the host to eat more and store fat in the fat cells. This will lead to weight gain. In addition to stress in fat cells, the immune system plays a role in this process, too.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Mariman, Edwin, Supervisor
  • van Baak, Marleen, Supervisor
Award date23 Jun 2017
Place of PublicationMaastricht
Publication statusPublished - 2017


  • yo-yo effect
  • stress in fat cells
  • immune system

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