Gastrointestinal Transit Time, Glucose Homeostasis and Metabolic Health: Modulation by Dietary Fibers

Mattea Muller, Emanuel E. Canfora, Ellen E. Blaak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

105 Citations (Web of Science)

Abstract

Gastrointestinal transit time may be an important determinant of glucose homeostasis and metabolic health through effects on nutrient absorption and microbial composition, among other mechanisms. Modulation of gastrointestinal transit may be one of the mechanisms underlying the beneficial health effects of dietary fibers. These effects include improved glucose homeostasis and a reduced risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. In this review, we first discuss the regulation of gastric emptying rate, small intestinal transit and colonic transit as well as their relation to glucose homeostasis and metabolic health. Subsequently, we briefly address the reported health effects of different dietary fibers and discuss to what extent the fiber-induced health benefits may be mediated through modulation of gastrointestinal transit.

Original languageEnglish
Article number275
Number of pages18
JournalNutrients
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2018

Keywords

  • dietary fiber
  • gastrointestinal transit
  • microbiota
  • obesity
  • type 2 diabetes
  • DEPENDENT DIABETIC-PATIENTS
  • SUSTAINED PECTIN INGESTION
  • SMALL-INTESTINAL TRANSIT
  • MIGRATING MOTOR COMPLEX
  • GUT MICROBIOTA
  • GUAR GUM
  • INSULIN SENSITIVITY
  • CEREAL-FIBER
  • WHOLE-GRAIN
  • BOWEL FUNCTION

Cite this