Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist

A. B. Beckers, D. Keszthelyi, A. Fikree, L. Vork, A. Masclee, A. D. Farmer, Q. Aziz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Web of Science)
57 Downloads (Pure)

Abstract

BackgroundJoint hypermobility syndrome (JHS)/Ehlers-Danlos syndrome hypermobility type (EDS-HT) is the most common hereditary non-inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal (GI) symptoms. Furthermore, JHS/EDS-HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome.

PurposeThe aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS/EDS-HT. In addition, we consider the clinical implications of the diagnosis and treatment of JHS/EDS-HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders.

Original languageEnglish
Article numbere13013
Number of pages10
JournalNeurogastroenterology and Motility
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Ehlers-Danlos syndrome
  • functional dyspepsia
  • functional GI disorders
  • joint hypermobility syndrome
  • ORTHOSTATIC TACHYCARDIA SYNDROME
  • IRRITABLE-BOWEL-SYNDROME
  • ANXIETY DISORDERS
  • CONNECTIVE-TISSUE
  • PSYCHOLOGICAL DISTRESS
  • CELIAC-DISEASE
  • TENASCIN-X
  • DYSFUNCTION
  • MANIFESTATIONS
  • PAIN

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