Gastric Carcinogenesis and Potential Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Receptor: An Observational Histopathological Study

Sylvester R Groen, Daniel Keszthelyi*, Arpad Szallasi, Jara A van Veghel, Annick M E Alleleyn, Kata Cseko, Zsuzsanna Helyes, Iryna Samarska, Heike I Grabsch, Ad A M Masclee, Zsa Zsa R M Weerts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The potential role of the transient receptor potential Vanilloid 1 (TRPV1) non-selective cation channel in gastric carcinogenesis remains unclear. The main objective of this study was to evaluate TRPV1 expression in gastric cancer (GC) and precursor lesions compared with controls. Patient inclusion was based on a retrospective review of pathology records. Patients were subdivided into five groups: Helicobacter pylori (H. pylori)-associated gastritis with gastric intestinal metaplasia (GIM) (n = 12), chronic atrophic gastritis (CAG) with GIM (n = 13), H. pylori-associated gastritis without GIM (n = 19), GC (n = 6) and controls (n = 5). TRPV1 expression was determined with immunohistochemistry and was significantly higher in patients with H. pylori-associated gastritis compared with controls (p = 0.002). TRPV1 expression was even higher in the presence of GIM compared with patients without GIM and controls (p < 0.001). There was a complete loss of TRPV1 expression in patients with GC. TRPV1 expression seems to contribute to gastric-mucosal inflammation and precursors of GC, which significantly increases in cancer precursor lesions but is completely lost in GC. These findings suggest TRPV1 expression to be a potential marker for precancerous conditions and a target for individualized treatment. Longitudinal studies are necessary to further address the role of TRPV1 in gastric carcinogenesis.

Original languageEnglish
Article number8294
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume25
Issue number15
DOIs
Publication statusPublished - 30 Jul 2024

Keywords

  • H. pylori
  • TRPV1
  • gastric cancer
  • gastritis
  • intestinal metaplasia
  • transient receptor potential vanilloid-1
  • Humans
  • TRPV Cation Channels/metabolism genetics
  • Stomach Neoplasms/metabolism pathology
  • Male
  • Female
  • Middle Aged
  • Aged
  • Helicobacter Infections/metabolism complications pathology
  • Carcinogenesis/metabolism pathology
  • Retrospective Studies
  • Precancerous Conditions/metabolism pathology
  • Helicobacter pylori/pathogenicity
  • Metaplasia/metabolism pathology
  • Gastritis/metabolism pathology microbiology
  • Adult
  • Immunohistochemistry
  • Gastric Mucosa/metabolism pathology
  • Gastritis, Atrophic/metabolism pathology

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