GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study

Lize Hermans, Oron Levin, Celine Maes, Peter van Ruitenbeek, Kirstin-Friederike Heise, Richard A E Edden, Nicolaas A J Puts, Ronald Peeters, Bradley R King, Raf L J Meesen, Inge Leunissen, Stephan P Swinnen, Koen Cuypers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels.

Original languageEnglish
Pages (from-to)168-177
Number of pages10
JournalNeurobiology of Aging
Volume65
DOIs
Publication statusPublished - May 2018

Keywords

  • Aging
  • Gamma-aminobutyric acid (GABA)
  • Magnetic resonance spectroscopy (MRS)
  • Transcranial magnetic stimulation (TMS)
  • Intracortical inhibition
  • Interhemispheric inhibition
  • TRANSCRANIAL MAGNETIC STIMULATION
  • HUMAN MOTOR CORTEX
  • WHITE-MATTER MICROSTRUCTURE
  • AGE-RELATED DIFFERENCES
  • IN-VIVO H-1-MRS
  • RESONANCE-SPECTROSCOPY
  • PHYSIOLOGICAL MEASURES
  • BRAIN-STIMULATION
  • AGING ALTERS
  • LIFE-SPAN
  • Humans
  • Healthy Volunteers
  • Neural Inhibition/physiology
  • Rest/physiology
  • Synaptic Transmission
  • Motor Cortex/physiology
  • Transcranial Magnetic Stimulation
  • Young Adult
  • Adult
  • Female
  • Sensorimotor Cortex/metabolism
  • Magnetic Resonance Spectroscopy
  • Healthy Aging/metabolism
  • gamma-Aminobutyric Acid/metabolism
  • Cortical Excitability/physiology
  • Aged

Cite this

Hermans, Lize ; Levin, Oron ; Maes, Celine ; van Ruitenbeek, Peter ; Heise, Kirstin-Friederike ; Edden, Richard A E ; Puts, Nicolaas A J ; Peeters, Ronald ; King, Bradley R ; Meesen, Raf L J ; Leunissen, Inge ; Swinnen, Stephan P ; Cuypers, Koen. / GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults : an MRS-TMS study. In: Neurobiology of Aging. 2018 ; Vol. 65. pp. 168-177.
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title = "GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study",
abstract = "Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels.",
keywords = "Aging, Gamma-aminobutyric acid (GABA), Magnetic resonance spectroscopy (MRS), Transcranial magnetic stimulation (TMS), Intracortical inhibition, Interhemispheric inhibition, TRANSCRANIAL MAGNETIC STIMULATION, HUMAN MOTOR CORTEX, WHITE-MATTER MICROSTRUCTURE, AGE-RELATED DIFFERENCES, IN-VIVO H-1-MRS, RESONANCE-SPECTROSCOPY, PHYSIOLOGICAL MEASURES, BRAIN-STIMULATION, AGING ALTERS, LIFE-SPAN, Humans, Healthy Volunteers, Neural Inhibition/physiology, Rest/physiology, Synaptic Transmission, Motor Cortex/physiology, Transcranial Magnetic Stimulation, Young Adult, Adult, Female, Sensorimotor Cortex/metabolism, Magnetic Resonance Spectroscopy, Healthy Aging/metabolism, gamma-Aminobutyric Acid/metabolism, Cortical Excitability/physiology, Aged",
author = "Lize Hermans and Oron Levin and Celine Maes and {van Ruitenbeek}, Peter and Kirstin-Friederike Heise and Edden, {Richard A E} and Puts, {Nicolaas A J} and Ronald Peeters and King, {Bradley R} and Meesen, {Raf L J} and Inge Leunissen and Swinnen, {Stephan P} and Koen Cuypers",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = "5",
doi = "10.1016/j.neurobiolaging.2018.01.023",
language = "English",
volume = "65",
pages = "168--177",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Science",

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Hermans, L, Levin, O, Maes, C, van Ruitenbeek, P, Heise, K-F, Edden, RAE, Puts, NAJ, Peeters, R, King, BR, Meesen, RLJ, Leunissen, I, Swinnen, SP & Cuypers, K 2018, 'GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study', Neurobiology of Aging, vol. 65, pp. 168-177. https://doi.org/10.1016/j.neurobiolaging.2018.01.023

GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults : an MRS-TMS study. / Hermans, Lize; Levin, Oron; Maes, Celine; van Ruitenbeek, Peter; Heise, Kirstin-Friederike; Edden, Richard A E; Puts, Nicolaas A J; Peeters, Ronald; King, Bradley R; Meesen, Raf L J; Leunissen, Inge; Swinnen, Stephan P; Cuypers, Koen.

In: Neurobiology of Aging, Vol. 65, 05.2018, p. 168-177.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults

T2 - an MRS-TMS study

AU - Hermans, Lize

AU - Levin, Oron

AU - Maes, Celine

AU - van Ruitenbeek, Peter

AU - Heise, Kirstin-Friederike

AU - Edden, Richard A E

AU - Puts, Nicolaas A J

AU - Peeters, Ronald

AU - King, Bradley R

AU - Meesen, Raf L J

AU - Leunissen, Inge

AU - Swinnen, Stephan P

AU - Cuypers, Koen

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels.

AB - Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74 years) and 28 young adults (19-34 years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels.

KW - Aging

KW - Gamma-aminobutyric acid (GABA)

KW - Magnetic resonance spectroscopy (MRS)

KW - Transcranial magnetic stimulation (TMS)

KW - Intracortical inhibition

KW - Interhemispheric inhibition

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - HUMAN MOTOR CORTEX

KW - WHITE-MATTER MICROSTRUCTURE

KW - AGE-RELATED DIFFERENCES

KW - IN-VIVO H-1-MRS

KW - RESONANCE-SPECTROSCOPY

KW - PHYSIOLOGICAL MEASURES

KW - BRAIN-STIMULATION

KW - AGING ALTERS

KW - LIFE-SPAN

KW - Humans

KW - Healthy Volunteers

KW - Neural Inhibition/physiology

KW - Rest/physiology

KW - Synaptic Transmission

KW - Motor Cortex/physiology

KW - Transcranial Magnetic Stimulation

KW - Young Adult

KW - Adult

KW - Female

KW - Sensorimotor Cortex/metabolism

KW - Magnetic Resonance Spectroscopy

KW - Healthy Aging/metabolism

KW - gamma-Aminobutyric Acid/metabolism

KW - Cortical Excitability/physiology

KW - Aged

U2 - 10.1016/j.neurobiolaging.2018.01.023

DO - 10.1016/j.neurobiolaging.2018.01.023

M3 - Article

C2 - 29494863

VL - 65

SP - 168

EP - 177

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -