FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

Rowan F. van Golen, Pim B. Olthof, Daniel A. Lionarons, Megan J. Reiniers, Lindy K. Alles, Zehra Uz, Lianne de Haan, Bulent Ergin, Dirk R. de Waart, Adrie Maas, Joanne Verheij, Peter L. Jansen, Steven W. Olde Darnink, Frank G. Schaap, Thomas M. van Gulik, Michel Heger*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number16529
Number of pages10
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 8 Nov 2018

Keywords

  • FARNESOID-X-RECEPTOR
  • PORTAL-VEIN EMBOLIZATION
  • BILE-ACID
  • HEPATIC REGENERATION
  • PARTIAL-HEPATECTOMY
  • PROTECTS
  • STEATOSIS
  • DRAINAGE
  • EXPRESSION
  • PROLIFERATION

Cite this

van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L., Ergin, B., de Waart, D. R., Maas, A., Verheij, J., Jansen, P. L., Darnink, S. W. O., Schaap, F. G., van Gulik, T. M., & Heger, M. (2018). FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis. Scientific Reports, 8, [16529]. https://doi.org/10.1038/s41598-018-33070-1