FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

Rowan F. van Golen; Pim B. Olthof; Daniel A. Lionarons; Megan J. Reiniers; Lindy K. Alles; Zehra Uz; Lianne de Haan; Bulent Ergin; Dirk R. de Waart; Adrie Maas; Joanne Verheij; Peter L. Jansen; Steven W. Olde Darnink; Frank G. Schaap; Thomas M. van Gulik; Michel Heger

doi:10.1038/s41598-018-33070-1

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

Rowan F. van Golen, Pim B. Olthof, Daniel A. Lionarons, Megan J. Reiniers, Lindy K. Alles, Zehra Uz, Lianne de Haan, Bulent Ergin, Dirk R. de Waart, Adrie Maas, Joanne Verheij, Peter L. Jansen, Steven W. Olde Darnink, Frank G. Schaap, Thomas M. van Gulik, Michel Heger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	16529
Number of pages	10
Journal	Scientific Reports
Volume	8
DOIs	https://doi.org/10.1038/s41598-018-33070-1
Publication status	Published - 8 Nov 2018

Keywords

FARNESOID-X-RECEPTOR
PORTAL-VEIN EMBOLIZATION
BILE-ACID
HEPATIC REGENERATION
PARTIAL-HEPATECTOMY
PROTECTS
STEATOSIS
DRAINAGE
EXPRESSION
PROLIFERATION

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10.1038/s41598-018-33070-1

Cite this

van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L., Ergin, B., de Waart, D. R., Maas, A., Verheij, J., Jansen, P. L., Darnink, S. W. O., Schaap, F. G., van Gulik, T. M., & Heger, M. (2018). FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis. Scientific Reports, 8, [16529]. https://doi.org/10.1038/s41598-018-33070-1

van Golen, Rowan F. ; Olthof, Pim B. ; Lionarons, Daniel A. ; Reiniers, Megan J. ; Alles, Lindy K. ; Uz, Zehra ; de Haan, Lianne ; Ergin, Bulent ; de Waart, Dirk R. ; Maas, Adrie ; Verheij, Joanne ; Jansen, Peter L. ; Darnink, Steven W. Olde ; Schaap, Frank G. ; van Gulik, Thomas M. ; Heger, Michel. / FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis. In: Scientific Reports. 2018 ; Vol. 8.

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title = "FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis",

keywords = "FARNESOID-X-RECEPTOR, PORTAL-VEIN EMBOLIZATION, BILE-ACID, HEPATIC REGENERATION, PARTIAL-HEPATECTOMY, PROTECTS, STEATOSIS, DRAINAGE, EXPRESSION, PROLIFERATION",

author = "{van Golen}, {Rowan F.} and Olthof, {Pim B.} and Lionarons, {Daniel A.} and Reiniers, {Megan J.} and Alles, {Lindy K.} and Zehra Uz and {de Haan}, Lianne and Bulent Ergin and {de Waart}, {Dirk R.} and Adrie Maas and Joanne Verheij and Jansen, {Peter L.} and Darnink, {Steven W. Olde} and Schaap, {Frank G.} and {van Gulik}, {Thomas M.} and Michel Heger",

year = "2018",

month = nov,

day = "8",

doi = "10.1038/s41598-018-33070-1",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

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van Golen, RF, Olthof, PB, Lionarons, DA, Reiniers, MJ, Alles, LK, Uz, Z, de Haan, L, Ergin, B, de Waart, DR, Maas, A, Verheij, J, Jansen, PL, Darnink, SWO, Schaap, FG, van Gulik, TM & Heger, M 2018, 'FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis', Scientific Reports, vol. 8, 16529. https://doi.org/10.1038/s41598-018-33070-1

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis. / van Golen, Rowan F.; Olthof, Pim B.; Lionarons, Daniel A.; Reiniers, Megan J.; Alles, Lindy K.; Uz, Zehra; de Haan, Lianne; Ergin, Bulent; de Waart, Dirk R.; Maas, Adrie; Verheij, Joanne; Jansen, Peter L.; Darnink, Steven W. Olde; Schaap, Frank G.; van Gulik, Thomas M.; Heger, Michel.

In: Scientific Reports, Vol. 8, 16529, 08.11.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

AU - van Golen, Rowan F.

AU - Olthof, Pim B.

AU - Lionarons, Daniel A.

AU - Reiniers, Megan J.

AU - Alles, Lindy K.

AU - Uz, Zehra

AU - de Haan, Lianne

AU - Ergin, Bulent

AU - de Waart, Dirk R.

AU - Maas, Adrie

AU - Verheij, Joanne

AU - Jansen, Peter L.

AU - Darnink, Steven W. Olde

AU - Schaap, Frank G.

AU - van Gulik, Thomas M.

AU - Heger, Michel

PY - 2018/11/8

Y1 - 2018/11/8

KW - FARNESOID-X-RECEPTOR

KW - PORTAL-VEIN EMBOLIZATION

KW - BILE-ACID

KW - HEPATIC REGENERATION

KW - PARTIAL-HEPATECTOMY

KW - PROTECTS

KW - STEATOSIS

KW - DRAINAGE

KW - EXPRESSION

KW - PROLIFERATION

U2 - 10.1038/s41598-018-33070-1

DO - 10.1038/s41598-018-33070-1

M3 - Article

C2 - 30409980

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 16529

ER -