Abstract
In this issue of Blood, Nogami et al report on a novel factor V (FV) gene mutation (FV Trp1920?Arg, FVNara) associated with activated protein C (APC) resistance and a severe thrombotic phenotype in a young Japanese patient. Since the affected amino acid residue is located in the light chain of FV, far from the known APC-cleavage sites, this discovery may afford new insights into the molecular mechanisms of APC resistance.
Original language | English |
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Pages (from-to) | 2288-2289 |
Journal | Blood |
Volume | 123 |
Issue number | 15 |
DOIs | |
Publication status | Published - 10 Apr 2014 |