FV and APC resistance: the plot thickens

Elisabetta Castoldi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In this issue of Blood, Nogami et al report on a novel factor V (FV) gene mutation (FV Trp1920?Arg, FVNara) associated with activated protein C (APC) resistance and a severe thrombotic phenotype in a young Japanese patient. Since the affected amino acid residue is located in the light chain of FV, far from the known APC-cleavage sites, this discovery may afford new insights into the molecular mechanisms of APC resistance.
Original languageEnglish
Pages (from-to)2288-2289
Issue number15
Publication statusPublished - 10 Apr 2014


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