Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.
|Publication status||Published - 2016|
|Event||International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems - Eindhoven, Netherlands|
Duration: 20 Jun 2016 → 24 Jun 2016
|Conference||International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems|
|Abbreviated title||IPMU 2016|
|Period||20/06/16 → 24/06/16|