Fuzzy Modeling for Vitamin B12 Deficiency

Anna Wilbik; Saskia van Loon; Arjen-Kars Boer; Uzay Kaymak; Volkher Scharnhorst

doi:10.1007/978-3-319-40596-4_39

Fuzzy Modeling for Vitamin B12 Deficiency

Anna Wilbik^*, Saskia van Loon, Arjen-Kars Boer, Uzay Kaymak, Volkher Scharnhorst

^*Corresponding author for this work

Research output: Contribution to conference › Paper › Academic

Abstract

Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.

Original language	English
Pages	462-471
DOIs	https://doi.org/10.1007/978-3-319-40596-4_39
Publication status	Published - 2016
Externally published	Yes
Event	International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems - Eindhoven, Netherlands Duration: 20 Jun 2016 → 24 Jun 2016

Conference

Conference	International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems
Abbreviated title	IPMU 2016
Country/Territory	Netherlands
City	Eindhoven
Period	20/06/16 → 24/06/16

Access to Document

10.1007/978-3-319-40596-4_39

Cite this

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title = "Fuzzy Modeling for Vitamin B12 Deficiency",

abstract = "Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.",

author = "Anna Wilbik and Loon, {Saskia van} and Arjen-Kars Boer and Uzay Kaymak and Volkher Scharnhorst",

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AU - Loon, Saskia van

AU - Boer, Arjen-Kars

AU - Kaymak, Uzay

AU - Scharnhorst, Volkher

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AB - Blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead plasma methylmalonic acid (MMA) levels can be measured because MMA concentrations increase relatively early in the course of vitamin B12 deficiency. However, MMA levels in plasma may also be increased due to renal failure. In this paper we estimate the influence of the kidney function on MMA levels in plasma by using fuzzy inference systems. Using this method diagnosing vitamin B12 deficiencies could be improved when kidney failure is present.

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