Functional network connectivity during rest and task conditions: A comparative study

M.R. Arbabshirani, M. Havlicek, K.A. Kiehl, G.D. Pearlson, V.D. Calhoun

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Functional connectivity (FC) examines temporal statistical dependencies among distant brain regions by means of seed-based analysis or independent component analysis (ICA). Spatial ICA also makes it possible to investigate FC at the network level, termed functional network connectivity (FNC). The dynamics of each network (ICA component), which may consist of several remote regions is described by the ICA time-course of that network; hence, FNC studies statistical dependencies among ICA time-courses. In this article, we compare comprehensively FNC in the resting state and during performance of an auditory oddball (AOD) task in 28 healthy subjects on relevant (nonartifactual) brain networks. The results show global FNC decrease during the performance of the task. In addition, we show that specific networks enlarge and/or demonstrate higher activity during the performance of the task. The results suggest that performing an active task like AOD may be facilitated by recruiting more neurons and higher activation of related networks rather than collaboration among different brain networks. We also evaluated the impact of temporal filtering on FNC analyses. Results showed that the results are not significantly affected by filtering. Hum Brain Mapp 34:2959-2971, 2013.

Original languageEnglish
Pages (from-to)2959-2971
Number of pages13
JournalHuman Brain Mapping
Volume34
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • AUDITORY ODDBALL TASK
  • CORTEX
  • DEFAULT MODE NETWORK
  • FLUCTUATIONS
  • FMRI DATA
  • HUMAN BRAIN
  • INDEPENDENT COMPONENT ANALYSIS
  • MRI DATA
  • SCHIZOPHRENIA
  • STATE DATA
  • fMRI
  • functional network connectivity
  • independent component analysis

Cite this

Arbabshirani, M. R., Havlicek, M., Kiehl, K. A., Pearlson, G. D., & Calhoun, V. D. (2013). Functional network connectivity during rest and task conditions: A comparative study. Human Brain Mapping, 34(11), 2959-2971. https://doi.org/10.1002/hbm.22118