TY - JOUR
T1 - Functional connectivity of paired default mode network subregions in patients with eye trauma
AU - Xing, Zheng Mao
AU - Song, Dan
AU - Hu, Jin Yu
AU - Zhou, Xian Mei
AU - Liao, Xuan
AU - Chen, Cheng
AU - Wei, Hong
AU - Kang, Min
AU - Ling, Qian
AU - He, Liang Qi
AU - Liu, Zhen Zhe
AU - Zou, Jie
AU - Chen, Xu
AU - Wu, Zhen Kai
AU - Shao, Yi
N1 - Funding Information:
Further, ET also inevitably causes damage to various structural eye tissues, seriously affecting the physiological functions of the eye, including movement, vision, and feeling. Damage to various eye structures can result in changes in the DMN region, and patients with ET may also exhibit DMN-specific alterations[50]. Previous studies have linked changes in eye function to alterations in neuronal connections[51], and impacts on eye function can affect the binocular properties of neurons in the primary visual fields; however, relevant research on characteristic cerebral cortex DMN pathological changes in patients with ET are lacking. Our study is the first to evaluate FC between paired DMN subregions with the aim of determining the abnormal changes in the cerebral cortex motor area in patients with ET. The BA17 area is part of the primary visual cortex, which is the first region to receive visual information in this part of the brain[52-53]. Further, the advanced visual cortex can mediate conscious intuition, after synthesizing visual information; however, in our study, we did not detect any decrease in region-to-region connectivity in DMN sub-regions in patients with ET. Hence, there is no reduction of information or enhanced stimulation to the senior cortex in patients with ET, which does not appear to impair the function of various DMN subregions. This abnormal connectivity may underline the decline in emotional or cognitive ability observed in patients with ET. Further, we did not detect any significant correlations of abnormal FC between paired DMN subregions with clinical parameters. Nevertheless, our results reveal alterations in FC between intrinsic DMN subregions, which will assist analysis of the mechanisms underlying ET. Integrative comparisons of the types and degree of ET would provide additional information regarding how ET, particularly extraocular muscle injury caused by ocular trauma, can affect FC in DMN subregions. This study has some limitations. First, the number of samples used to study DMN in patients with ET was relatively small. Second, we have not excluded the influence of psychological or physiological abnormalities due to ocular trauma on interregional FC. Third, the changes in the cerebral cortex motor area in patients with ET are likely to be related to different types of ocular trauma, as well as the course and severity of the condition, which were not considered in our analyses. Future research should conduct a more comprehensive analysis of the DMN with regards to the afore mentioned issues. In conclusion, changes in the FC between brain areas, including the DMN, can be evaluated using rs-fMRI, and reflect the relationships between various eye diseases and related brain regions, which have been evaluated in other studies (Table 3[34,44,46,52,54-55]). ET damages the normal physiological activit1y of eye, thereby disrupting FC within DMN subregions. ACKNOWLEDGEMENTS Foundations: Supported by National Natural Science Foundation of China (No.82160195; No.82460203); Key R&D Program of Jiangxi Province (No.20223BBH80014); Science and Technology Project of Jiangxi Province Health Commission of Traditional Chinese Medicine (No. 2022B258); Science and Technology Project of Jiangxi Health Commission (No.202210017). Conflicts of Interest: Xing ZM, None; Song D, None; Hu JY, None; Zhou XM, None; Liao X, None; Chen C, None; Wei H, None; Kang M, None; Ling Q, None; He LQ, None; Liu ZZ, None; Zou J, None; Chen X, None; Wu ZK, None; Shao Y, None. REFERENCES 1 Wang JD, Xu L, Wang YX, You QS, Zhang JS, Jonas JB. Prevalence and incidence of ocular trauma in North China: the Beijing eye study. Acta Ophthalmol 2012;90(1):e61-7. 2 Cai MM, Zhang J. Epidemiological characteristics of work-related ocular trauma in southwest region of China. Int J Environ Res Public Health 2015;12(8):9864-9875. 3 Huang X, Li HJ, Ye L, Zhang Y, Wei R, Zhong YL, Peng DC, Shao Y. Altered regional homogeneity in patients with unilateral acute open-globe injury: a resting-state functional MRI study. Neuropsychiatr Dis Treat 2016;12:1901-1906. 4 Nawani N, Vazirani J, Ojha H, Sangwan VS. Conjunctival pedicle flap in management of open globe injury with corneal tissue loss. BMJ Case Rep 2016;2016:bcr2015213703. 5 Smith MP, Colyer MH, Weichel ED, Stutzman RD. Traumatic cataracts secondary to combat ocular trauma. J Cataract Refract Surg 2015;41(8):1693-1698. 6 Koksaldi S, Utine CA, Kayabasi M. Management of suprachoroidal
Publisher Copyright:
© 2024 International Journal of Ophthalmology (c/o Editorial Office). All rights reserved.
PY - 2024/12/18
Y1 - 2024/12/18
N2 - AIM: To study functional brain abnormalities in patients with eye trauma (ET) and to discuss the pathophysiological mechanisms of ET. METHODS: Totally 31 ET patients and 31 healthy controls (HCs) were recruited. The age, gender, and educational background characteristics of the two groups were similar. After functional magnetic resonance imaging (fMRI) scanning, the subjects' spontaneous brain activity was evaluated with the functional connectivity (FC) method. Receiver operating characteristic (ROC) curve analysis was used to classify the data. Pearson's correlation analysis was used to explore the relationship between FC values in specific brain regions and clinical behaviors in patients with ET. RESULTS: Significantly increased FC between several regions was identified including the medial prefrontal cortex (MPFC) and left hippocampus formations (HF), the MPFC and left inferior parietal lobule (IPL), the left IPL and left medial temporal lobe (MTL), the left IPL and right MTL, and the right IPL and left MTL. No decreased region-to-region connectivity was detected in default mode network (DMN) sub-regions in patients with ET. Compared with HCs, ET patients exhibited significantly increased FC between several paired DMN regions, as follows: posterior cingulate cortex (PCC) and right HF (HF.R, t=2.196, P=0.032), right inferior parietal cortices (IPC.R) and left MTL (MTL.L, t=2.243, P=0.029), and right MTL (MTL.R) and HF.R (t=2.236, P=0.029). CONCLUSION: FC values in multiple brain regions of ET patients are abnormal, suggesting that these brain regions in ET patients may be dysfunctional, which may help to reveal the pathophysiological mechanisms of ET.
AB - AIM: To study functional brain abnormalities in patients with eye trauma (ET) and to discuss the pathophysiological mechanisms of ET. METHODS: Totally 31 ET patients and 31 healthy controls (HCs) were recruited. The age, gender, and educational background characteristics of the two groups were similar. After functional magnetic resonance imaging (fMRI) scanning, the subjects' spontaneous brain activity was evaluated with the functional connectivity (FC) method. Receiver operating characteristic (ROC) curve analysis was used to classify the data. Pearson's correlation analysis was used to explore the relationship between FC values in specific brain regions and clinical behaviors in patients with ET. RESULTS: Significantly increased FC between several regions was identified including the medial prefrontal cortex (MPFC) and left hippocampus formations (HF), the MPFC and left inferior parietal lobule (IPL), the left IPL and left medial temporal lobe (MTL), the left IPL and right MTL, and the right IPL and left MTL. No decreased region-to-region connectivity was detected in default mode network (DMN) sub-regions in patients with ET. Compared with HCs, ET patients exhibited significantly increased FC between several paired DMN regions, as follows: posterior cingulate cortex (PCC) and right HF (HF.R, t=2.196, P=0.032), right inferior parietal cortices (IPC.R) and left MTL (MTL.L, t=2.243, P=0.029), and right MTL (MTL.R) and HF.R (t=2.236, P=0.029). CONCLUSION: FC values in multiple brain regions of ET patients are abnormal, suggesting that these brain regions in ET patients may be dysfunctional, which may help to reveal the pathophysiological mechanisms of ET.
KW - brain region
KW - eye trauma
KW - functional connectivity
U2 - 10.18240/ijo.2024.12.13
DO - 10.18240/ijo.2024.12.13
M3 - Article
SN - 2222-3959
VL - 17
SP - 2248
EP - 2255
JO - International Journal of Ophthalmology
JF - International Journal of Ophthalmology
IS - 12
ER -