Functional characterization of human brown adipose tissue metabolism

Marie Anne Richard, Hannah Pallubinsky, Denis P. Blondin*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

14 Citations (Web of Science)

Abstract

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Original languageEnglish
Pages (from-to)1261-1286
Number of pages26
JournalBiochemical Journal
Volume477
Issue number7
DOIs
Publication statusPublished - Apr 2020

Keywords

  • COLD-ACTIVATED BROWN
  • POSITRON-EMISSION-TOMOGRAPHY
  • IN-VIVO ASSESSMENT
  • BODY-MASS INDEX
  • FATTY-ACID
  • MAGNETIC-RESONANCE
  • GLUCOSE-UPTAKE
  • INDUCED THERMOGENESIS
  • INSULIN SENSITIVITY
  • UNCOUPLING PROTEIN

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