Research Output per year
Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Participants with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of (pre-)diabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study was designed to investigate whether functional brain networks are affected in type 2 diabetes and pre-diabetes. Forty-seven participants with diabetes, 47 pre-diabetic participants, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency compared with controls. The network measures of the pre-diabetic participants fell between those of the diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. To conclude, participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the pre-diabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as compensatory mechanism for cognitive decrements.
- PARTICIPANTS AGED 24-81
- NORMATIVE DATA
- METABOLIC SYNDROME
- CONNECTIVITY CHANGES
Erratum: Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study (vol 65, pg 2404, 2016)van Bussel, F. C. G., Backes, W. H., van Veenendaal, T. M., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., Sep, S. J. S., Dagnelie, P. C., Schaper, N., Stehouwer, C. D. A., Wildberger, J. E. & Jansen, J. F. A., Feb 2017, In : Diabetes. 66, 2, p. 560
Research output: Contribution to journal › Erratum / corrigendum › Academic