Abstract

Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Participants with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of (pre-)diabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study was designed to investigate whether functional brain networks are affected in type 2 diabetes and pre-diabetes. Forty-seven participants with diabetes, 47 pre-diabetic participants, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency compared with controls. The network measures of the pre-diabetic participants fell between those of the diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. To conclude, participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the pre-diabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as compensatory mechanism for cognitive decrements.

Original languageEnglish
Pages (from-to)2404-2413
Number of pages10
JournalDiabetes
Volume65
Issue number8
Early online date23 May 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • PARTICIPANTS AGED 24-81
  • NORMATIVE DATA
  • METABOLIC SYNDROME
  • CONNECTIVITY CHANGES
  • MULTIPLE-SCLEROSIS
  • MENSTRUAL-CYCLE
  • WORKING-MEMORY
  • STATE
  • MRI
  • RISK

Cite this

@article{909bdd2ee75647c99a6e1fc292f3a614,
title = "Functional brain networks are altered in type 2 diabetes and pre-diabetes signs for compensation of cognitive decrements? - The Maastricht Study: signs for compensation of cognitive decrements? - The Maastricht Study",
abstract = "Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Participants with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of (pre-)diabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study was designed to investigate whether functional brain networks are affected in type 2 diabetes and pre-diabetes. Forty-seven participants with diabetes, 47 pre-diabetic participants, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency compared with controls. The network measures of the pre-diabetic participants fell between those of the diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. To conclude, participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the pre-diabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as compensatory mechanism for cognitive decrements.",
keywords = "PARTICIPANTS AGED 24-81, NORMATIVE DATA, METABOLIC SYNDROME, CONNECTIVITY CHANGES, MULTIPLE-SCLEROSIS, MENSTRUAL-CYCLE, WORKING-MEMORY, STATE, MRI, RISK",
author = "{van Bussel}, {Frank C G} and Backes, {Walter H} and {van Veenendaal}, {Tamar M} and Hofman, {Paul A M} and {van Boxtel}, {Martin P J} and Schram, {Miranda T} and Sep, {Simone J S} and Dagnelie, {Pieter C} and Nicolaas Schaper and Stehouwer, {Coen D A} and Wildberger, {Joachim E} and Jaap Jansen",
note = "{\circledC} 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.",
year = "2016",
month = "8",
doi = "10.2337/db16-0128",
language = "English",
volume = "65",
pages = "2404--2413",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "8",

}

TY - JOUR

T1 - Functional brain networks are altered in type 2 diabetes and pre-diabetes signs for compensation of cognitive decrements? - The Maastricht Study

T2 - signs for compensation of cognitive decrements? - The Maastricht Study

AU - van Bussel, Frank C G

AU - Backes, Walter H

AU - van Veenendaal, Tamar M

AU - Hofman, Paul A M

AU - van Boxtel, Martin P J

AU - Schram, Miranda T

AU - Sep, Simone J S

AU - Dagnelie, Pieter C

AU - Schaper, Nicolaas

AU - Stehouwer, Coen D A

AU - Wildberger, Joachim E

AU - Jansen, Jaap

N1 - © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

PY - 2016/8

Y1 - 2016/8

N2 - Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Participants with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of (pre-)diabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study was designed to investigate whether functional brain networks are affected in type 2 diabetes and pre-diabetes. Forty-seven participants with diabetes, 47 pre-diabetic participants, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency compared with controls. The network measures of the pre-diabetic participants fell between those of the diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. To conclude, participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the pre-diabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as compensatory mechanism for cognitive decrements.

AB - Type 2 diabetes is associated with cognitive decrements, accelerated cognitive decline, and increased risk for dementia. Participants with the metabolic syndrome, a major risk factor for diabetes, may display comparable cognitive decrements as seen in type 2 diabetes. Currently, the impact of (pre-)diabetes on cognition and the underlying organization of functional brain networks still remain to be elucidated. This study was designed to investigate whether functional brain networks are affected in type 2 diabetes and pre-diabetes. Forty-seven participants with diabetes, 47 pre-diabetic participants, and 45 control participants underwent detailed cognitive testing and 3-Tesla resting state functional MRI. Graph theoretical network analysis was performed to investigate alterations in functional cerebral networks. Participants with diabetes displayed altered network measures, characterized by a higher normalized cluster coefficient and higher local efficiency compared with controls. The network measures of the pre-diabetic participants fell between those of the diabetes and control participants. Lower processing speed was associated with shorter path length and higher global efficiency. To conclude, participants with type 2 diabetes have altered functional brain networks. This alteration is already apparent in the pre-diabetic stage to a somewhat lower level, hinting at functional reorganization of the cerebral networks as compensatory mechanism for cognitive decrements.

KW - PARTICIPANTS AGED 24-81

KW - NORMATIVE DATA

KW - METABOLIC SYNDROME

KW - CONNECTIVITY CHANGES

KW - MULTIPLE-SCLEROSIS

KW - MENSTRUAL-CYCLE

KW - WORKING-MEMORY

KW - STATE

KW - MRI

KW - RISK

U2 - 10.2337/db16-0128

DO - 10.2337/db16-0128

M3 - Article

C2 - 27217484

VL - 65

SP - 2404

EP - 2413

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 8

ER -