Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy

Gerhard S Drenthen, Floor Fasen, Eric L A Fonseca Wald, Walter H Backes, Albert P Aldenkamp, R Jeroen Vermeulen, Mariette Debeij-van Hall, Jos Hendriksen, Sylvia Klinkenberg, Jacobus F A Jansen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore, the possible relation of the functional network abnormalities with epilepsy and neurocognitive characteristics is studied. Seventeen children with childhood CAE (aged 9.2 ± 2.1 years) and 15 controls (aged 9.8 ± 1.8 years) were included. Resting state functional MRI was acquired to study the functional network. Using graph theoretical analysis, three global metrics of the functional network were investigated: the characteristic path length, the clustering coefficient, and the small-worldness. A multivariable linear regression model including age, sex, and subject motion as covariates was used to investigate group differences in the graph metrics. Subsequently, relations of the graph metrics with epilepsy and neurocognitive characteristics were assessed. Longer path lengths, weaker clustering and a lower small-world network topology were observed in children with CAE compared to controls. Moreover, longer path lengths were related to a longer duration of CAE and a higher number of absence seizure per hour. Clustering and small-worldness were not significantly related to epilepsy or neurocognitive characteristics. The organization of the functional network of children with CAE is less efficient compared to controls, and is related to disease duration. These preliminary findings suggest that CAE is associated with alterations in the functional network.

Original languageEnglish
Article number102264
Number of pages6
JournalNeuroImage: Clinical
Early online date23 Apr 2020
Publication statusPublished - 2020


  • Cognitive performance
  • Functional mri
  • Graph theory
  • Network analysis
  • Seizures

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