Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors

M. van Heinsbergen; N. den Haan; A. J. Maaskant-Braat; J. Melenhorst; E. H. Belgers; J. W. Leijtens; J. G. Bloemen; H. J. Rutten; N. D. Bouvy; M. L. Janssen-Heijnen; J. L. Konsten

doi:10.1111/codi.14818

Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors

M. van Heinsbergen^*, N. den Haan, A. J. Maaskant-Braat, J. Melenhorst, E. H. Belgers, J. W. Leijtens, J. G. Bloemen, H. J. Rutten, N. D. Bouvy, M. L. Janssen-Heijnen, J. L. Konsten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Web of Science)

105 Downloads (Pure)

Abstract

Aim Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. The aim of this study was to investigate the prevalence of functional abdominal complaints and related QoL after colon cancer surgery compared with patients with similar complaints after rectal cancer surgery.

Method All patients who underwent colorectal cancer resections between January 2008 and December 2015, and who were free of colostomy for at least 1 year, were eligible (n = 2136). Bowel function was assessed by the LARS score, QoL by the EORTC QLQ-C30 and QLQ-CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories.

Results A total of 1495 patients (70.0%) were included in the analyses, of whom 1145 had a colonic and 350 a rectal tumour. Symptoms of LARS were observed in 55% after rectal cancer resection compared with 21% after colon cancer resection. Female gender (OR 1.88, CI 1.392-2.528) and a previous diverting stoma (OR 1.84, CI 1.14-2.97) were independently associated with a higher prevalence of LARS after colon cancer surgery. Patients with LARS after colon cancer surgery performed significantly worse in most QoL domains.

Conclusion The results of this study highlight the presence of LARS-like symptoms after surgery for colonic cancer. Patients suffering from major LARS-like symptoms after colon resection reported the same debilitating effect on their QoL as patients with major LARS after rectal resection. This should be addressed by colorectal cancer specialists in order to adequately inform patients.

Original language	English
Pages (from-to)	136-145
Number of pages	10
Journal	Colorectal Disease
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/codi.14818
Publication status	Published - Feb 2020

Keywords

Health-related quality of life
bowel dysfunction
low anterior resection syndrome
colorectal cancer
colonic resection
LOW ANTERIOR RESECTION
COLORECTAL-CANCER
RECTAL-CANCER
NEOADJUVANT THERAPY
DYSFUNCTION
IMPACT
VALIDATION
CONTINENCE
SURVIVORS
DIARRHEA

Access to Document

10.1111/codi.14818

Full text Final published version, 335 KBLicence: Taverne

Cite this

van Heinsbergen, M., den Haan, N., Maaskant-Braat, A. J., Melenhorst, J., Belgers, E. H., Leijtens, J. W., Bloemen, J. G., Rutten, H. J., Bouvy, N. D., Janssen-Heijnen, M. L., & Konsten, J. L. (2020). Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors. Colorectal Disease, 22(2), 136-145. https://doi.org/10.1111/codi.14818

@article{589abaa11a404e89be75c63f4592d542,

title = "Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors",

abstract = "Aim Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. The aim of this study was to investigate the prevalence of functional abdominal complaints and related QoL after colon cancer surgery compared with patients with similar complaints after rectal cancer surgery.Method All patients who underwent colorectal cancer resections between January 2008 and December 2015, and who were free of colostomy for at least 1 year, were eligible (n = 2136). Bowel function was assessed by the LARS score, QoL by the EORTC QLQ-C30 and QLQ-CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories.Results A total of 1495 patients (70.0%) were included in the analyses, of whom 1145 had a colonic and 350 a rectal tumour. Symptoms of LARS were observed in 55% after rectal cancer resection compared with 21% after colon cancer resection. Female gender (OR 1.88, CI 1.392-2.528) and a previous diverting stoma (OR 1.84, CI 1.14-2.97) were independently associated with a higher prevalence of LARS after colon cancer surgery. Patients with LARS after colon cancer surgery performed significantly worse in most QoL domains.Conclusion The results of this study highlight the presence of LARS-like symptoms after surgery for colonic cancer. Patients suffering from major LARS-like symptoms after colon resection reported the same debilitating effect on their QoL as patients with major LARS after rectal resection. This should be addressed by colorectal cancer specialists in order to adequately inform patients.",

keywords = "Health-related quality of life, bowel dysfunction, low anterior resection syndrome, colorectal cancer, colonic resection, LOW ANTERIOR RESECTION, COLORECTAL-CANCER, RECTAL-CANCER, NEOADJUVANT THERAPY, DYSFUNCTION, IMPACT, VALIDATION, CONTINENCE, SURVIVORS, DIARRHEA",

author = "{van Heinsbergen}, M. and {den Haan}, N. and Maaskant-Braat, {A. J.} and J. Melenhorst and Belgers, {E. H.} and Leijtens, {J. W.} and Bloemen, {J. G.} and Rutten, {H. J.} and Bouvy, {N. D.} and Janssen-Heijnen, {M. L.} and Konsten, {J. L.}",

note = "Publisher Copyright: Colorectal Disease {\textcopyright} 2019 The Association of Coloproctology of Great Britain and Ireland",

year = "2020",

month = feb,

doi = "10.1111/codi.14818",

language = "English",

volume = "22",

pages = "136--145",

journal = "Colorectal Disease",

issn = "1462-8910",

publisher = "Wiley",

number = "2",

}

van Heinsbergen, M, den Haan, N, Maaskant-Braat, AJ, Melenhorst, J, Belgers, EH, Leijtens, JW, Bloemen, JG, Rutten, HJ, Bouvy, ND , Janssen-Heijnen, ML & Konsten, JL 2020, 'Functional bowel complaints and quality of life after surgery for colon cancer: prevalence and predictive factors', Colorectal Disease, vol. 22, no. 2, pp. 136-145. https://doi.org/10.1111/codi.14818

TY - JOUR

T1 - Functional bowel complaints and quality of life after surgery for colon cancer

T2 - prevalence and predictive factors

AU - van Heinsbergen, M.

AU - den Haan, N.

AU - Maaskant-Braat, A. J.

AU - Melenhorst, J.

AU - Belgers, E. H.

AU - Leijtens, J. W.

AU - Bloemen, J. G.

AU - Rutten, H. J.

AU - Bouvy, N. D.

AU - Janssen-Heijnen, M. L.

AU - Konsten, J. L.

PY - 2020/2

Y1 - 2020/2

N2 - Aim Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. The aim of this study was to investigate the prevalence of functional abdominal complaints and related QoL after colon cancer surgery compared with patients with similar complaints after rectal cancer surgery.Method All patients who underwent colorectal cancer resections between January 2008 and December 2015, and who were free of colostomy for at least 1 year, were eligible (n = 2136). Bowel function was assessed by the LARS score, QoL by the EORTC QLQ-C30 and QLQ-CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories.Results A total of 1495 patients (70.0%) were included in the analyses, of whom 1145 had a colonic and 350 a rectal tumour. Symptoms of LARS were observed in 55% after rectal cancer resection compared with 21% after colon cancer resection. Female gender (OR 1.88, CI 1.392-2.528) and a previous diverting stoma (OR 1.84, CI 1.14-2.97) were independently associated with a higher prevalence of LARS after colon cancer surgery. Patients with LARS after colon cancer surgery performed significantly worse in most QoL domains.Conclusion The results of this study highlight the presence of LARS-like symptoms after surgery for colonic cancer. Patients suffering from major LARS-like symptoms after colon resection reported the same debilitating effect on their QoL as patients with major LARS after rectal resection. This should be addressed by colorectal cancer specialists in order to adequately inform patients.

AB - Aim Low anterior resection syndrome (LARS) severely affects the quality of life (QoL) of patients after surgery for rectal cancer. There are very few studies that have investigated LARS-like symptoms and their effect on QoL after colon cancer surgery. The aim of this study was to investigate the prevalence of functional abdominal complaints and related QoL after colon cancer surgery compared with patients with similar complaints after rectal cancer surgery.Method All patients who underwent colorectal cancer resections between January 2008 and December 2015, and who were free of colostomy for at least 1 year, were eligible (n = 2136). Bowel function was assessed by the LARS score, QoL by the EORTC QLQ-C30 and QLQ-CR29 questionnaires. QoL was compared between the LARS score categories and tumour height categories.Results A total of 1495 patients (70.0%) were included in the analyses, of whom 1145 had a colonic and 350 a rectal tumour. Symptoms of LARS were observed in 55% after rectal cancer resection compared with 21% after colon cancer resection. Female gender (OR 1.88, CI 1.392-2.528) and a previous diverting stoma (OR 1.84, CI 1.14-2.97) were independently associated with a higher prevalence of LARS after colon cancer surgery. Patients with LARS after colon cancer surgery performed significantly worse in most QoL domains.Conclusion The results of this study highlight the presence of LARS-like symptoms after surgery for colonic cancer. Patients suffering from major LARS-like symptoms after colon resection reported the same debilitating effect on their QoL as patients with major LARS after rectal resection. This should be addressed by colorectal cancer specialists in order to adequately inform patients.

KW - Health-related quality of life

KW - bowel dysfunction

KW - low anterior resection syndrome

KW - colorectal cancer

KW - colonic resection

KW - LOW ANTERIOR RESECTION

KW - COLORECTAL-CANCER

KW - RECTAL-CANCER

KW - NEOADJUVANT THERAPY

KW - DYSFUNCTION

KW - IMPACT

KW - VALIDATION

KW - CONTINENCE

KW - SURVIVORS

KW - DIARRHEA

U2 - 10.1111/codi.14818

DO - 10.1111/codi.14818

M3 - Article

C2 - 31397962

SN - 1462-8910

VL - 22

SP - 136

EP - 145

JO - Colorectal Disease

JF - Colorectal Disease

IS - 2

ER -