Full Spectrum of Reported Symptoms of Bilateral Vestibulopathy Needs Further Investigation: A Systematic Review

Florence Lucieer*, Stijn Duijn, Vincent Van Rompaey, Angelica Perez Fornos, Nils Guinand, Jean Philippe Guyot, Herman Kingma, Raymond van de Berg

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Citations (Web of Science)

Abstract

Objective: To systematically review the symptoms reported by patients with bilateral vestibulopathy (BV) in clinical studies and case reports. This would serve as the first step in establishing a validated patient-reported outcome measures (PROM) for BV. Methods: A search on symptoms reported by patients with BV was performed in PubMed, and all publications covering these symptoms were included. Exclusion criteria comprised reviews and insufficient details about the frequency of occurrence of symptoms. Results: 1,442 articles were retrieved. 88 studies were included (41 clinical studies, 47 case reports). In consensus, 68 descriptions of symptoms were classified into 6 common and generic symptoms. Frequency of symptoms in clinical studies and case reports were reviewed, respectively; imbalance (91 and 86%), chronic dizziness (58 and 62%), oscillopsia (50 and 70%), and recurrent vertigo (33 and 67%). BV could be accompanied by hearing loss (33 and 43%) and tinnitus (15 and 36%). 15 clinical studies and 10 case reports reported symptoms beyond vestibular and hearing deficits such as limited social activities, depression, concentration, and memory impairment and reduced quality of life in general. Conclusion: The literature on BV symptomatology mainly focuses on classic symptoms such as imbalance and oscillopsia, while only few report additional symptoms such as cognitive memory impairment and performing dual tasks. In fact, none of the reviewed clinical studies and case reports provided a comprehensive overview of BV symptoms. To develop a validated PROM, qualitative research using semi-structured and unstructured interviews is needed to explore the full spectrum of BV symptoms.
Original languageEnglish
Article number352
Pages (from-to)1-7
Number of pages7
JournalFrontiers in Neurology
Volume9
DOIs
Publication statusPublished - 4 Jun 2018

Keywords

  • bilateral vestibulopathy
  • symptoms
  • dizziness
  • vertigo
  • imbalance
  • oscillopsia
  • bilateral vestibular hypofunction
  • patient-reported outcome measures
  • EVOKED MYOGENIC POTENTIALS
  • LABYRINTHINE-DEFECTIVE SUBJECTS
  • QUALITY-OF-LIFE
  • GENTAMICIN OTOTOXICITY
  • DIAGNOSTIC-CRITERIA
  • CEREBELLAR-ATAXIA
  • CAUSATIVE FACTORS
  • SPATIAL MEMORY
  • CASE SERIES
  • FOLLOW-UP

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