Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Studies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left-sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma-related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1-week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left-sided activation in response to the negative picture correlated with lower levels of psychopathology. Left-sided activation in the trauma-related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left-sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma-free individuals (n = 15). Our findings suggest that state-dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals.

Original languageEnglish
Article number12779
Number of pages21
JournalPsychophysiology
Volume55
Issue number1
Early online date15 Mar 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Journal Article
  • symptom provocation
  • PSYCHOMETRIC PROPERTIES
  • POSTTRAUMATIC-STRESS-DISORDER
  • MOTOR-VEHICLE ACCIDENTS
  • frontal alpha asymmetry
  • MEMORY DEVELOPMENT
  • INTERNAL CONSISTENCY
  • STRUCTURED INVENTORY
  • ANXIETY DISORDER
  • intrusions
  • posttraumatic stress disorder
  • diary
  • INDIVIDUAL-DIFFERENCES
  • BRAIN ELECTRICAL-ACTIVITY
  • ALPHA ASYMMETRY

Cite this

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title = "Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD",
abstract = "Studies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left-sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma-related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1-week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left-sided activation in response to the negative picture correlated with lower levels of psychopathology. Left-sided activation in the trauma-related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left-sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma-free individuals (n = 15). Our findings suggest that state-dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals.",
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author = "Thomas Meyer and Quaedflieg, {Conny W E M} and Kim Weijland and Koen Schruers and Harald Merckelbach and Tom Smeets",
note = "{\circledC} 2017 Society for Psychophysiological Research.",
year = "2018",
month = "1",
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language = "English",
volume = "55",
journal = "Psychophysiology",
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Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD. / Meyer, Thomas; Quaedflieg, Conny W E M; Weijland, Kim; Schruers, Koen; Merckelbach, Harald; Smeets, Tom.

In: Psychophysiology, Vol. 55, No. 1, 12779, 01.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD

AU - Meyer, Thomas

AU - Quaedflieg, Conny W E M

AU - Weijland, Kim

AU - Schruers, Koen

AU - Merckelbach, Harald

AU - Smeets, Tom

N1 - © 2017 Society for Psychophysiological Research.

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N2 - Studies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left-sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma-related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1-week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left-sided activation in response to the negative picture correlated with lower levels of psychopathology. Left-sided activation in the trauma-related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left-sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma-free individuals (n = 15). Our findings suggest that state-dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals.

AB - Studies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left-sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma-related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1-week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left-sided activation in response to the negative picture correlated with lower levels of psychopathology. Left-sided activation in the trauma-related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left-sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma-free individuals (n = 15). Our findings suggest that state-dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals.

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KW - frontal alpha asymmetry

KW - MEMORY DEVELOPMENT

KW - INTERNAL CONSISTENCY

KW - STRUCTURED INVENTORY

KW - ANXIETY DISORDER

KW - intrusions

KW - posttraumatic stress disorder

KW - diary

KW - INDIVIDUAL-DIFFERENCES

KW - BRAIN ELECTRICAL-ACTIVITY

KW - ALPHA ASYMMETRY

U2 - 10.1111/psyp.12779

DO - 10.1111/psyp.12779

M3 - Article

C2 - 28295402

VL - 55

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

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