TY - JOUR
T1 - From the exposome to mechanistic understanding of chemical-induced adverse effects
AU - Escher, Beate I.
AU - Hackermuller, Joerg
AU - Polte, Tobias
AU - Scholz, Stefan
AU - Aigner, Achim
AU - Altenburger, Rolf
AU - Boehme, Alexander
AU - Bopp, Stephanie K.
AU - Brack, Werner
AU - Busch, Wibke
AU - Chadeau-Hyam, Marc
AU - Covaci, Adrian
AU - Eisentraeger, Adolf
AU - Galligan, James J.
AU - Garcia-Reyero, Natalia
AU - Hartung, Thomas
AU - Hein, Michaela
AU - Herberth, Gunda
AU - Jahnke, Annika
AU - Kleinjans, Jos
AU - Kluever, Nils
AU - Krauss, Martin
AU - Lamoree, Marja
AU - Lehmann, Irina
AU - Luckenbach, Till
AU - Miller, Gary W.
AU - Mueller, Andrea
AU - Phillips, David H.
AU - Reemtsma, Thorsten
AU - Rolle-Kampczyk, Ulrike
AU - Schueuermann, Gerrit
AU - Schwikowski, Benno
AU - Tan, Yu-Mei
AU - Trump, Saskia
AU - Walter-Rohde, Susanne
AU - Wambaugh, John F.
PY - 2017/2
Y1 - 2017/2
N2 - The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistit understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. (C) 2016 The Authors. Published by Elsevier Ltd.
AB - The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistit understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. (C) 2016 The Authors. Published by Elsevier Ltd.
KW - Exposome
KW - AOP
KW - Systems toxicology
KW - Systems biology
KW - Systems chemistry
KW - Risk assessment
KW - EFFECT-DIRECTED ANALYSIS
KW - INTEGRATED TESTING STRATEGIES
KW - ENVIRONMENTAL RISK-ASSESSMENT
KW - HUMAN HAZARD CHARACTERIZATION
KW - GENE-EXPRESSION DATA
KW - OUTCOME PATHWAYS
KW - PERFLUORINATED COMPOUNDS
KW - ORGANIC MICROPOLLUTANTS
KW - SYSTEMS TOXICOLOGY
KW - SAFETY ASSESSMENT
U2 - 10.1016/j.envint.2016.11.029
DO - 10.1016/j.envint.2016.11.029
M3 - (Systematic) Review article
C2 - 27939949
SN - 0160-4120
VL - 99
SP - 97
EP - 106
JO - Environment International
JF - Environment International
ER -