From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health

Chiara Renzi; Nadine Provencal; Katherine C. Bassil; Kathinka Evers; Ulrik Kihlbom; Elizabeth J. Radford; Ilona Koupil; Bertram Mueller-Myhsok; Mats G. Hansson; Bart P. F. Rutten

doi:10.1016/bs.pmbts.2018.04.011

From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health

Chiara Renzi, Nadine Provencal, Katherine C. Bassil, Kathinka Evers, Ulrik Kihlbom, Elizabeth J. Radford, Ilona Koupil, Bertram Mueller-Myhsok, Mats G. Hansson, Bart P. F. Rutten^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

2 Citations (Web of Science)

Abstract

The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.

Original language	English
Title of host publication	Neuroepigenetics and Mental Illness
Editors	Bart P.F. Rutten
Pages	299-323
Number of pages	25
Volume	158
DOIs	https://doi.org/10.1016/bs.pmbts.2018.04.011
Publication status	Published - 1 Jan 2018

Publication series

Series	Progress in Molecular Biology and Translational Science
ISSN	1877-1173

Keywords

GENE-ENVIRONMENT INTERACTIONS
GENOME-WIDE ASSOCIATION
BIOPSYCHOSOCIAL MODEL
SOCIOECONOMIC-STATUS
SELECTIVE ATTENTION
RESEARCH STRATEGIES
BRAIN-DEVELOPMENT
NETWORK MEDICINE
DNA METHYLATION
MATERNAL-CARE

Access to Document

10.1016/bs.pmbts.2018.04.011

Cite this

Renzi, C., Provencal, N., Bassil, K. C., Evers, K., Kihlbom, U., Radford, E. J., Koupil, I., Mueller-Myhsok, B., Hansson, M. G., & Rutten, B. P. F. (2018). From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health. In B. P. F. Rutten (Ed.), Neuroepigenetics and Mental Illness (Vol. 158, pp. 299-323). Progress in Molecular Biology and Translational Science https://doi.org/10.1016/bs.pmbts.2018.04.011

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abstract = "The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.",

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author = "Chiara Renzi and Nadine Provencal and Bassil, {Katherine C.} and Kathinka Evers and Ulrik Kihlbom and Radford, {Elizabeth J.} and Ilona Koupil and Bertram Mueller-Myhsok and Hansson, {Mats G.} and Rutten, {Bart P. F.}",

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language = "English",

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Renzi, C, Provencal, N, Bassil, KC, Evers, K, Kihlbom, U, Radford, EJ, Koupil, I, Mueller-Myhsok, B, Hansson, MG & Rutten, BPF 2018, From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health. in BPF Rutten (ed.), Neuroepigenetics and Mental Illness. vol. 158, Progress in Molecular Biology and Translational Science, pp. 299-323. https://doi.org/10.1016/bs.pmbts.2018.04.011

From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health. / Renzi, Chiara; Provencal, Nadine; Bassil, Katherine C. et al.

Neuroepigenetics and Mental Illness. ed. / Bart P.F. Rutten. Vol. 158 2018. p. 299-323 (Progress in Molecular Biology and Translational Science).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

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