From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health

Chiara Renzi, Nadine Provencal, Katherine C. Bassil, Kathinka Evers, Ulrik Kihlbom, Elizabeth J. Radford, Ilona Koupil, Bertram Mueller-Myhsok, Mats G. Hansson, Bart P. F. Rutten*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.
Original languageEnglish
Title of host publicationNeuroepigenetics and Mental Illness
EditorsBart P.F. Rutten
Pages299-323
Number of pages25
Volume158
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

SeriesProgress in Molecular Biology and Translational Science
ISSN1877-1173

Keywords

  • GENE-ENVIRONMENT INTERACTIONS
  • GENOME-WIDE ASSOCIATION
  • BIOPSYCHOSOCIAL MODEL
  • SOCIOECONOMIC-STATUS
  • SELECTIVE ATTENTION
  • RESEARCH STRATEGIES
  • BRAIN-DEVELOPMENT
  • NETWORK MEDICINE
  • DNA METHYLATION
  • MATERNAL-CARE

Fingerprint

Dive into the research topics of 'From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health'. Together they form a unique fingerprint.

Cite this