From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries

J. Damoiseaux; N. Agmon-Levin; M. Van Blerk; V. Chopyak; C. Eriksson; I. Heijnen; M. Herold; K. Hogasen; L. Musset; A. Radice; M.J. Sousa; M. Viander; Y. Shoenfeld

From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries

J. Damoiseaux^*, N. Agmon-Levin, M. Van Blerk, V. Chopyak, C. Eriksson, I. Heijnen, M. Herold, K. Hogasen, L. Musset, A. Radice, M.J. Sousa, M. Viander, Y. Shoenfeld

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS: A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries. RESULTS: The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries. CONCLUSIONS: Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.

Original language	English
Pages (from-to)	539-546
Journal	Clinical and Experimental Rheumatology
Volume	32
Issue number	4
Publication status	Published - 1 Jan 2014

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http://www.ncbi.nlm.nih.gov/pubmed/?term=24983380

Cite this

Damoiseaux, J., Agmon-Levin, N., Van Blerk, M., Chopyak, V., Eriksson, C., Heijnen, I., Herold, M., Hogasen, K., Musset, L., Radice, A., Sousa, M. J., Viander, M., & Shoenfeld, Y. (2014). From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries. Clinical and Experimental Rheumatology, 32(4), 539-546. http://www.ncbi.nlm.nih.gov/pubmed/?term=24983380

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title = "From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries",

abstract = "OBJECTIVES: One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS: A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries. RESULTS: The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries. CONCLUSIONS: Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.",

author = "J. Damoiseaux and N. Agmon-Levin and {Van Blerk}, M. and V. Chopyak and C. Eriksson and I. Heijnen and M. Herold and K. Hogasen and L. Musset and A. Radice and M.J. Sousa and M. Viander and Y. Shoenfeld",

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Damoiseaux, J, Agmon-Levin, N, Van Blerk, M, Chopyak, V, Eriksson, C, Heijnen, I, Herold, M, Hogasen, K, Musset, L, Radice, A, Sousa, MJ, Viander, M & Shoenfeld, Y 2014, 'From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries', Clinical and Experimental Rheumatology, vol. 32, no. 4, pp. 539-546. <http://www.ncbi.nlm.nih.gov/pubmed/?term=24983380>

TY - JOUR

T1 - From ANA-screening to antigen-specificity: an EASI-survey on the daily practice in European countries

AU - Damoiseaux, J.

AU - Agmon-Levin, N.

AU - Van Blerk, M.

AU - Chopyak, V.

AU - Eriksson, C.

AU - Heijnen, I.

AU - Herold, M.

AU - Hogasen, K.

AU - Musset, L.

AU - Radice, A.

AU - Sousa, M.J.

AU - Viander, M.

AU - Shoenfeld, Y.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVES: One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS: A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries. RESULTS: The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries. CONCLUSIONS: Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.

AB - OBJECTIVES: One of the main goals of the European Autoimmunity Standardisation Initiative (EASI) is the harmonisation of test-algorithms for autoantibodies related to systemic autoimmune rheumatic diseases (SARD). METHODS: A questionnaire was used to gather information on methodology, interpretation, and the algorithm for detection of anti-nuclear antibodies (ANA) in relation to their antigen-specificity. The questionnaire was sent to 1200 laboratories in 12 European countries. RESULTS: The response rate was 47.2%. The results reveal not only apparent differences between countries, but also within countries. CONCLUSIONS: Awareness of these differences may as such already stimulate harmonisation, but the observed differences may also direct recommendations that may further contribute to achieving the EASI goal of harmonisation of autoimmune diagnostics for SARD.

M3 - Article

SN - 0392-856X

VL - 32

SP - 539

EP - 546

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 4

ER -