Frequent Cognitive Impairment in Patients With Disorders Along the Heart-Brain Axis

Astrid M. Hooghiemstra*, Anna E. Leeuwis, Anne Suzannne Bertens, Geert Jan Biessels, Michiel L. Bots, Hans-Peter Brunner-La Rocca, Jacoba P. Greving, L. Jaap Kappelle, Robert J. van Oostenbrugge, Albert C. van Rossum, Wiesje M. van der Flier, Heart-Brain Connection Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Web of Science)

Abstract

Background and Purpose-Patients with cardiovascular disease are at increased risk for cognitive decline. We studied the occurrence and profile of cognitive impairment in 3 patient groups as exemplar conditions of hemodynamic disturbances at different levels of the heart-brain axis, including patients with heart failure (HF), carotid occlusive disease (COD), and patients with cognitive complaints and vascular brain injury on magnetic resonance imaging (possible vascular cognitive impairment [VCI]).

Methods-In 555 participants (160 HF, 107 COD, 160 possible VCI, 128 reference participants; 689 years; 36% F; Mini-Mental State Examination 282), we assessed cognitive functioning with a comprehensive test battery. Test scores were transformed into z-scores. Compound z-scores were constructed for: memory, language, attention/psychomotor speed, executive functioning, and global cognitive functioning. We rated cognitive domains as impaired when z-score

Results-Age, sex, and education adjusted global cognitive functioning z-score was lower in patients with COD (beta [SE]=-0.46 [0.10], P

Conclusions-A substantial part of patients with HF and COD had cognitive impairment, which warrants vigilance for the occurrence of cognitive impairment. These results underline the importance of an integrative approach in medicine in patients presenting with disorders in the heart-brain axis.

Original languageEnglish
Pages (from-to)3369-3375
Number of pages7
JournalStroke
Volume50
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • brain
  • cerebral small vessel diseases
  • cognitive impairment
  • dementia
  • heart failure
  • ASYMPTOMATIC CAROTID STENOSIS
  • PARTICIPANTS AGED 24-81
  • PULSE-WAVE VELOCITY
  • NORMATIVE DATA
  • ARTERY OCCLUSION
  • DEMENTIA
  • EDUCATION
  • DECLINE
  • PERFORMANCE
  • PRESSURE

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