Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis

Arnaldo N. S. Silva, Jordy Coffa, Varsha Menon, Lindsay C. Hewitt, Kakoli Das, Yohei Miyagi, Dan Bottomley, Hayley Slaney, Toru Aoyama, Wolfram Mueller, Tomio Arai, Iain B. Tan, Niantao Deng, Xiu B. Chan, Patrick Tan, Akira Tsuburaya, Kentaro Sakamaki, Jeremy D. Hayden, Takaki Yoshikawa, Ilse ZondervanSuvi Savola, Heike I. Grabsch

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalAnnals of Surgery
Volume267
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • gastric cancer
  • gastric cancer heterogeneity
  • gene copy number status
  • lymph node metastasis
  • receptor tyrosine kinases
  • resistance mechanisms
  • DEPENDENT PROBE AMPLIFICATION
  • IN-SITU HYBRIDIZATION
  • LABEL PHASE-3 TRIAL
  • CLINICOPATHOLOGICAL SIGNIFICANCE
  • ACQUIRED-RESISTANCE
  • TARGETED THERAPIES
  • PROTEIN EXPRESSION
  • COLORECTAL-CANCER
  • CARCINOMA
  • HER2

Cite this

Silva, A. N. S., Coffa, J., Menon, V., Hewitt, L. C., Das, K., Miyagi, Y., Bottomley, D., Slaney, H., Aoyama, T., Mueller, W., Arai, T., Tan, I. B., Deng, N., Chan, X. B., Tan, P., Tsuburaya, A., Sakamaki, K., Hayden, J. D., Yoshikawa, T., ... Grabsch, H. I. (2018). Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. Annals of Surgery, 267(1), 114-121. https://doi.org/10.1097/SLA.0000000000002042