Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis

Arnaldo N. S. Silva; Jordy Coffa; Varsha Menon; Lindsay C. Hewitt; Kakoli Das; Yohei Miyagi; Dan Bottomley; Hayley Slaney; Toru Aoyama; Wolfram Mueller; Tomio Arai; Iain B. Tan; Niantao Deng; Xiu B. Chan; Patrick Tan; Akira Tsuburaya; Kentaro Sakamaki; Jeremy D. Hayden; Takaki Yoshikawa; Ilse Zondervan; Suvi Savola; Heike I. Grabsch

doi:10.1097/SLA.0000000000002042

Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis

Arnaldo N. S. Silva, Jordy Coffa, Varsha Menon, Lindsay C. Hewitt, Kakoli Das, Yohei Miyagi, Dan Bottomley, Hayley Slaney, Toru Aoyama, Wolfram Mueller, Tomio Arai, Iain B. Tan, Niantao Deng, Xiu B. Chan, Patrick Tan, Akira Tsuburaya, Kentaro Sakamaki, Jeremy D. Hayden, Takaki Yoshikawa, Ilse ZondervanSuvi Savola, Heike I. Grabsch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	114-121
Number of pages	8
Journal	Annals of Surgery
Volume	267
Issue number	1
DOIs	https://doi.org/10.1097/SLA.0000000000002042
Publication status	Published - 1 Jan 2018

Keywords

gastric cancer
gastric cancer heterogeneity
gene copy number status
lymph node metastasis
receptor tyrosine kinases
resistance mechanisms
DEPENDENT PROBE AMPLIFICATION
IN-SITU HYBRIDIZATION
LABEL PHASE-3 TRIAL
CLINICOPATHOLOGICAL SIGNIFICANCE
ACQUIRED-RESISTANCE
TARGETED THERAPIES
PROTEIN EXPRESSION
COLORECTAL-CANCER
CARCINOMA
HER2

Access to Document

10.1097/SLA.0000000000002042

http://eprints.whiterose.ac.uk/109942/1/ANNALS%20OF%20SURGERY%20Revised%20Manuscript_short.pdf

Cite this

Silva, A. N. S., Coffa, J., Menon, V., Hewitt, L. C., Das, K., Miyagi, Y., Bottomley, D., Slaney, H., Aoyama, T., Mueller, W., Arai, T., Tan, I. B., Deng, N., Chan, X. B., Tan, P., Tsuburaya, A., Sakamaki, K., Hayden, J. D., Yoshikawa, T., ... Grabsch, H. I. (2018). Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. Annals of Surgery, 267(1), 114-121. https://doi.org/10.1097/SLA.0000000000002042

Silva, Arnaldo N. S. ; Coffa, Jordy ; Menon, Varsha ; Hewitt, Lindsay C. ; Das, Kakoli ; Miyagi, Yohei ; Bottomley, Dan ; Slaney, Hayley ; Aoyama, Toru ; Mueller, Wolfram ; Arai, Tomio ; Tan, Iain B. ; Deng, Niantao ; Chan, Xiu B. ; Tan, Patrick ; Tsuburaya, Akira ; Sakamaki, Kentaro ; Hayden, Jeremy D. ; Yoshikawa, Takaki ; Zondervan, Ilse ; Savola, Suvi ; Grabsch, Heike I. / Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. In: Annals of Surgery. 2018 ; Vol. 267, No. 1. pp. 114-121.

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title = "Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis",

keywords = "gastric cancer, gastric cancer heterogeneity, gene copy number status, lymph node metastasis, receptor tyrosine kinases, resistance mechanisms, DEPENDENT PROBE AMPLIFICATION, IN-SITU HYBRIDIZATION, LABEL PHASE-3 TRIAL, CLINICOPATHOLOGICAL SIGNIFICANCE, ACQUIRED-RESISTANCE, TARGETED THERAPIES, PROTEIN EXPRESSION, COLORECTAL-CANCER, CARCINOMA, HER2",

author = "Silva, {Arnaldo N. S.} and Jordy Coffa and Varsha Menon and Hewitt, {Lindsay C.} and Kakoli Das and Yohei Miyagi and Dan Bottomley and Hayley Slaney and Toru Aoyama and Wolfram Mueller and Tomio Arai and Tan, {Iain B.} and Niantao Deng and Chan, {Xiu B.} and Patrick Tan and Akira Tsuburaya and Kentaro Sakamaki and Hayden, {Jeremy D.} and Takaki Yoshikawa and Ilse Zondervan and Suvi Savola and Grabsch, {Heike I.}",

year = "2018",

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doi = "10.1097/SLA.0000000000002042",

language = "English",

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Silva, ANS, Coffa, J, Menon, V, Hewitt, LC, Das, K, Miyagi, Y, Bottomley, D, Slaney, H, Aoyama, T, Mueller, W, Arai, T, Tan, IB, Deng, N, Chan, XB, Tan, P, Tsuburaya, A, Sakamaki, K, Hayden, JD, Yoshikawa, T, Zondervan, I, Savola, S & Grabsch, HI 2018, 'Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis', Annals of Surgery, vol. 267, no. 1, pp. 114-121. https://doi.org/10.1097/SLA.0000000000002042

Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. / Silva, Arnaldo N. S.; Coffa, Jordy; Menon, Varsha; Hewitt, Lindsay C.; Das, Kakoli; Miyagi, Yohei; Bottomley, Dan; Slaney, Hayley; Aoyama, Toru; Mueller, Wolfram; Arai, Tomio; Tan, Iain B.; Deng, Niantao; Chan, Xiu B.; Tan, Patrick; Tsuburaya, Akira; Sakamaki, Kentaro; Hayden, Jeremy D.; Yoshikawa, Takaki; Zondervan, Ilse; Savola, Suvi; Grabsch, Heike I.

In: Annals of Surgery, Vol. 267, No. 1, 01.01.2018, p. 114-121.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis

AU - Silva, Arnaldo N. S.

AU - Coffa, Jordy

AU - Menon, Varsha

AU - Hewitt, Lindsay C.

AU - Das, Kakoli

AU - Miyagi, Yohei

AU - Bottomley, Dan

AU - Slaney, Hayley

AU - Aoyama, Toru

AU - Mueller, Wolfram

AU - Arai, Tomio

AU - Tan, Iain B.

AU - Deng, Niantao

AU - Chan, Xiu B.

AU - Tan, Patrick

AU - Tsuburaya, Akira

AU - Sakamaki, Kentaro

AU - Hayden, Jeremy D.

AU - Yoshikawa, Takaki

AU - Zondervan, Ilse

AU - Savola, Suvi

AU - Grabsch, Heike I.

PY - 2018/1/1

Y1 - 2018/1/1

KW - gastric cancer

KW - gastric cancer heterogeneity

KW - gene copy number status

KW - lymph node metastasis

KW - receptor tyrosine kinases

KW - resistance mechanisms

KW - DEPENDENT PROBE AMPLIFICATION

KW - IN-SITU HYBRIDIZATION

KW - LABEL PHASE-3 TRIAL

KW - CLINICOPATHOLOGICAL SIGNIFICANCE

KW - ACQUIRED-RESISTANCE

KW - TARGETED THERAPIES

KW - PROTEIN EXPRESSION

KW - COLORECTAL-CANCER

KW - CARCINOMA

KW - HER2

U2 - 10.1097/SLA.0000000000002042

DO - 10.1097/SLA.0000000000002042

M3 - Article

C2 - 27779515

VL - 267

SP - 114

EP - 121

JO - Annals of Surgery

JF - Annals of Surgery

SN - 0003-4932

IS - 1

ER -