Frequency preference and attention effects across cortical depths in the human primary auditory cortex

F. de Martino, M. Moerel, K. Ugurbil, R. Goebel, E. Yacoub, E. Formisano

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Columnar arrangements of neurons with similar preference have been suggested as the fundamental processing units of the cerebral cortex. Within these columnar arrangements, feed-forward information enters at middle cortical layers whereas feedback information arrives at superficial and deep layers. This interplay of feed-forward and feedback processing is at the core of perception and behavior. Here we provide in vivo evidence consistent with a columnar organization of the processing of sound frequency in the human auditory cortex. We measure submillimeter functional responses to sound frequency sweeps at high magnetic fields (7 tesla) and show that frequency preference is stable through cortical depth in primary auditory cortex. Furthermore, we demonstrate that-in this highly columnar cortex-task demands sharpen the frequency tuning in superficial cortical layers more than in middle or deep layers. These findings are pivotal to understanding mechanisms of neural information processing and flow during the active perception of sounds.
Original languageEnglish
Pages (from-to)16036-16041
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number52
DOIs
Publication statusPublished - 29 Dec 2015

Keywords

  • columns
  • tonotopy
  • fMRI
  • 7-Tesla
  • depth-dependent
  • SPIN-ECHO
  • HUMAN BRAIN
  • 7 TESLA
  • COLUMNAR ORGANIZATION
  • INFERIOR COLLICULUS
  • LAMINAR SPECIFICITY
  • RECEPTIVE-FIELDS
  • SIGNAL CHANGES
  • GRADIENT-ECHO
  • FMRI

Cite this

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title = "Frequency preference and attention effects across cortical depths in the human primary auditory cortex",
abstract = "Columnar arrangements of neurons with similar preference have been suggested as the fundamental processing units of the cerebral cortex. Within these columnar arrangements, feed-forward information enters at middle cortical layers whereas feedback information arrives at superficial and deep layers. This interplay of feed-forward and feedback processing is at the core of perception and behavior. Here we provide in vivo evidence consistent with a columnar organization of the processing of sound frequency in the human auditory cortex. We measure submillimeter functional responses to sound frequency sweeps at high magnetic fields (7 tesla) and show that frequency preference is stable through cortical depth in primary auditory cortex. Furthermore, we demonstrate that-in this highly columnar cortex-task demands sharpen the frequency tuning in superficial cortical layers more than in middle or deep layers. These findings are pivotal to understanding mechanisms of neural information processing and flow during the active perception of sounds.",
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Frequency preference and attention effects across cortical depths in the human primary auditory cortex. / de Martino, F.; Moerel, M.; Ugurbil, K.; Goebel, R.; Yacoub, E.; Formisano, E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 52, 29.12.2015, p. 16036-16041.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Frequency preference and attention effects across cortical depths in the human primary auditory cortex

AU - de Martino, F.

AU - Moerel, M.

AU - Ugurbil, K.

AU - Goebel, R.

AU - Yacoub, E.

AU - Formisano, E.

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