Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

E. Peelen; M. Thewissen; S. Knippenberg; J. Smolders; A.H. Muris; P. Menheere; J.W. Tervaert; R. Hupperts; J. Damoiseaux

doi:10.1016/j.jneuroim.2013.02.014

Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

E. Peelen^*, M. Thewissen, S. Knippenberg, J. Smolders, A.H. Muris, P. Menheere, J.W. Tervaert, R. Hupperts, J. Damoiseaux

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-beta), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	258
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.02.014
Publication status	Published - 15 May 2013

Keywords

Multiple sclerosis
CD8
IL-17
IL-10
Immune modulation
MULTIPLE-SCLEROSIS PATIENTS
INTERFERON-GAMMA
PERIPHERAL-BLOOD
DOUBLE-BLIND
IFN-GAMMA
AUTOIMMUNE ENCEPHALOMYELITIS
GLATIRAMER ACETATE
DISEASE
SYSTEM
BETA

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Peelen, E., Thewissen, M., Knippenberg, S., Smolders, J., Muris, A. H., Menheere, P., Tervaert, J. W., Hupperts, R., & Damoiseaux, J. (2013). Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators. Journal of Neuroimmunology, 258(1-2), 77-84. https://doi.org/10.1016/j.jneuroim.2013.02.014

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title = "Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators",

abstract = "In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-beta), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.",

keywords = "Multiple sclerosis, CD8, IL-17, IL-10, Immune modulation, MULTIPLE-SCLEROSIS PATIENTS, INTERFERON-GAMMA, PERIPHERAL-BLOOD, DOUBLE-BLIND, IFN-GAMMA, AUTOIMMUNE ENCEPHALOMYELITIS, GLATIRAMER ACETATE, DISEASE, SYSTEM, BETA",

author = "E. Peelen and M. Thewissen and S. Knippenberg and J. Smolders and A.H. Muris and P. Menheere and J.W. Tervaert and R. Hupperts and J. Damoiseaux",

year = "2013",

month = may,

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doi = "10.1016/j.jneuroim.2013.02.014",

language = "English",

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Peelen, E, Thewissen, M, Knippenberg, S, Smolders, J, Muris, AH, Menheere, P, Tervaert, JW, Hupperts, R & Damoiseaux, J 2013, 'Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators', Journal of Neuroimmunology, vol. 258, no. 1-2, pp. 77-84. https://doi.org/10.1016/j.jneuroim.2013.02.014

TY - JOUR

T1 - Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

AU - Peelen, E.

AU - Thewissen, M.

AU - Knippenberg, S.

AU - Smolders, J.

AU - Muris, A.H.

AU - Menheere, P.

AU - Tervaert, J.W.

AU - Hupperts, R.

AU - Damoiseaux, J.

PY - 2013/5/15

Y1 - 2013/5/15

N2 - In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-beta), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

AB - In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-beta), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.

KW - Multiple sclerosis

KW - CD8

KW - IL-17

KW - IL-10

KW - Immune modulation

KW - MULTIPLE-SCLEROSIS PATIENTS

KW - INTERFERON-GAMMA

KW - PERIPHERAL-BLOOD

KW - DOUBLE-BLIND

KW - IFN-GAMMA

KW - AUTOIMMUNE ENCEPHALOMYELITIS

KW - GLATIRAMER ACETATE

KW - DISEASE

KW - SYSTEM

KW - BETA

U2 - 10.1016/j.jneuroim.2013.02.014

DO - 10.1016/j.jneuroim.2013.02.014

M3 - Article

C2 - 23517930

SN - 0165-5728

VL - 258

SP - 77

EP - 84

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

Abstract

Keywords

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