Fraction of IL-10+ and IL-17+ CD8 T cells is increased in MS patients in remission and during a relapse, but is not influenced by immune modulators

E. Peelen, M. Thewissen, S. Knippenberg, J. Smolders, A.H. Muris, P. Menheere, J.W. Tervaert, R. Hupperts, J. Damoiseaux

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12 Citations (Scopus)

Abstract

In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-beta), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.
Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalJournal of Neuroimmunology
Volume258
Issue number1-2
DOIs
Publication statusPublished - 15 May 2013

Keywords

  • Multiple sclerosis
  • CD8
  • IL-17
  • IL-10
  • Immune modulation
  • MULTIPLE-SCLEROSIS PATIENTS
  • INTERFERON-GAMMA
  • PERIPHERAL-BLOOD
  • DOUBLE-BLIND
  • IFN-GAMMA
  • AUTOIMMUNE ENCEPHALOMYELITIS
  • GLATIRAMER ACETATE
  • DISEASE
  • SYSTEM
  • BETA

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