TY - JOUR
T1 - Fluid intake and clinicopathological characteristics of bladder cancer
T2 - the West Midlands Bladder Cancer Prognosis Programme
AU - van Hensbergen, Mitch
AU - van Osch, Frits H. M.
AU - Jochems, Sylvia
AU - James, Nicholas D.
AU - Wallace, D. Michael A.
AU - Wesselius, Anke
AU - Cheng, K. K.
AU - Bryan, Richard T.
AU - Zeegers, M. P.
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - ObjectiveBetween 10 and 20% of bladder cancer patients who are diagnosed with nonmuscle-invasive bladder cancer will progress to muscle-invasive disease. Risk of progression depends on several factors at diagnosis including age, tumour stage, grade, size and number, and the presence or absence of carcinoma in situ. Fluid intake may be related to these factors.MethodsData of 1123 participants from the West Midlands Bladder Cancer Prognosis Programme were used. Data collection was via a semistructured questionnaire, and case report forms were used to collect clinicopathological data. Fluid intake was measured for six main categories: alcoholic fluids, hot fluids, fruit fluids, milk, fizzy drinks, and water, and converted into quintile variables. Multilevel mixed-effects linear regression was performed for every beverage category per clinicopathological variable and corrected for age, gender, and smoking status.ResultsAge at diagnosis was distributed differently amongst those in different total fluid intake quintiles (predicted means 71.5, 70.9, 71.5, 69.9, and 67.4, respectively) and showed a significant inverse linear trend in alcohol (P <0.01), hot fluids (P <0.01), and total fluids intake (P <0.01), in nonmuscle-invasive bladder cancer patients.ConclusionOur results suggest an inverse association for alcohol intake and total fluid intake with age at diagnosis. These results should be confirmed by future studies, alongside a possible (biological) mechanism that could influence tumour growth, and the effect of micturition frequency.
AB - ObjectiveBetween 10 and 20% of bladder cancer patients who are diagnosed with nonmuscle-invasive bladder cancer will progress to muscle-invasive disease. Risk of progression depends on several factors at diagnosis including age, tumour stage, grade, size and number, and the presence or absence of carcinoma in situ. Fluid intake may be related to these factors.MethodsData of 1123 participants from the West Midlands Bladder Cancer Prognosis Programme were used. Data collection was via a semistructured questionnaire, and case report forms were used to collect clinicopathological data. Fluid intake was measured for six main categories: alcoholic fluids, hot fluids, fruit fluids, milk, fizzy drinks, and water, and converted into quintile variables. Multilevel mixed-effects linear regression was performed for every beverage category per clinicopathological variable and corrected for age, gender, and smoking status.ResultsAge at diagnosis was distributed differently amongst those in different total fluid intake quintiles (predicted means 71.5, 70.9, 71.5, 69.9, and 67.4, respectively) and showed a significant inverse linear trend in alcohol (P <0.01), hot fluids (P <0.01), and total fluids intake (P <0.01), in nonmuscle-invasive bladder cancer patients.ConclusionOur results suggest an inverse association for alcohol intake and total fluid intake with age at diagnosis. These results should be confirmed by future studies, alongside a possible (biological) mechanism that could influence tumour growth, and the effect of micturition frequency.
KW - alcohol intake
KW - bladder cancer
KW - fluid intake
KW - tumour characteristics
KW - OCCUPATIONAL RISK-FACTORS
KW - ALCOHOL-CONSUMPTION
KW - URINARY-BLADDER
KW - LIFE-STYLE
KW - EPIDEMIOLOGY
KW - DRINKING
KW - NUTRITION
KW - ETIOLOGY
U2 - 10.1097/CEJ.0000000000000525
DO - 10.1097/CEJ.0000000000000525
M3 - Article
C2 - 32012137
SN - 0959-8278
VL - 29
SP - 110
EP - 118
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
IS - 2
ER -