Fluid flow as a driver of embryonic morphogenesis

Margo Daems, Hanna M Peacock, Elizabeth A V Jones*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Fluid flow is a powerful morphogenic force during embryonic development. The physical forces created by flowing fluids can either create morphogen gradients or be translated by mechanosensitive cells into biological changes in gene expression. In this Primer, we describe how fluid flow is created in different systems and highlight the important mechanosensitive signalling pathways involved for sensing and transducing flow during embryogenesis. Specifically, we describe how fluid flow helps establish left-right asymmetry in the early embryo and discuss the role of flow of blood, lymph and cerebrospinal fluid in sculpting the embryonic cardiovascular and nervous system.

Original languageEnglish
Article number185579
Number of pages15
JournalDevelopment
Volume147
Issue number15
DOIs
Publication statusPublished - 7 Aug 2020
Externally publishedYes

Keywords

  • Animals
  • Cardiovascular System/embryology
  • Embryo, Mammalian/embryology
  • Embryonic Development/physiology
  • Gene Expression Regulation, Developmental
  • Humans
  • Nervous System/embryology
  • Neurogenesis
  • Signal Transduction
  • Cerebrospinal fluid
  • CEREBROSPINAL-FLUID
  • Blood
  • Mechanosensation
  • SHEAR-STRESS
  • ENDOTHELIAL-CELLS
  • Cilia
  • VASCULAR DEVELOPMENT
  • LEFT-RIGHT ASYMMETRY
  • BLOOD-FLOW
  • MURAL CELL RECRUITMENT
  • PRIMARY CILIARY DYSKINESIA
  • Shear stress
  • ARTERIAL-VENOUS DIFFERENTIATION
  • TRANSCRIPTION FACTOR
  • Lymph

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