Flavonoids can replace alpha-tocopherol as an antioxidant

F.A.A. van Acker; O. Schouten; G.R.M.M. Haenen; W.J.F. van der Vijgh; A. Bast

doi:10.1016/S0014-5793(00)01517-9

Flavonoids can replace alpha-tocopherol as an antioxidant

F.A.A. van Acker^*, O. Schouten, G.R.M.M. Haenen, W.J.F. van der Vijgh, A. Bast

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Febs Letters
Volume	473
DOIs	https://doi.org/10.1016/S0014-5793(00)01517-9
Publication status	Published - 1 Jan 2000

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10.1016/S0014-5793(00)01517-9

Cite this

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title = "Flavonoids can replace alpha-tocopherol as an antioxidant",

abstract = "Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes. ",

author = "{van Acker}, F.A.A. and O. Schouten and G.R.M.M. Haenen and {van der Vijgh}, W.J.F. and A. Bast",

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doi = "10.1016/S0014-5793(00)01517-9",

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T1 - Flavonoids can replace alpha-tocopherol as an antioxidant

AU - van Acker, F.A.A.

AU - Schouten, O.

AU - Haenen, G.R.M.M.

AU - van der Vijgh, W.J.F.

AU - Bast, A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.

AB - Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.

U2 - 10.1016/S0014-5793(00)01517-9

DO - 10.1016/S0014-5793(00)01517-9

M3 - Article

SN - 0014-5793

VL - 473

SP - 145

EP - 148

JO - Febs Letters

JF - Febs Letters

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