Flavonoids can replace alpha-tocopherol as an antioxidant

F.A.A. van Acker*, O. Schouten, G.R.M.M. Haenen, W.J.F. van der Vijgh, A. Bast

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Endogenous antioxidants such as the lipid-soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate alpha-tocopherol via a so-called free radical reductase, The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in alpha-tocopherol. Introduction of antioxidant flavonoids, such as 7-monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH-dependent protection, suggesting that flavonoids can take over the role of alpha-tocopherol as a chain-breaking antioxidant in liver microsomal membranes.
Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalFebs Letters
Publication statusPublished - 1 Jan 2000


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