Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.

H. Kaiserova; T. Simunek; W.J. van der Vijgh; A. Bast; E. Kvasnickova

doi:10.1016/j.bbadis.2007.05.002

Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.

H. Kaiserova^*, T. Simunek, W.J. van der Vijgh, A. Bast, E. Kvasnickova

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AB - Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, anti

Original language	English
Pages (from-to)	1065-1074
Journal	Biochimica et Biophysica Acta-Molecular Basis of Disease
Volume	1772
Issue number	9
DOIs	https://doi.org/10.1016/j.bbadis.2007.05.002
Publication status	Published - 1 Jan 2007

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10.1016/j.bbadis.2007.05.002

Cite this

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title = "Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.",

abstract = "AB - Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, anti",

author = "H. Kaiserova and T. Simunek and {van der Vijgh}, W.J. and A. Bast and E. Kvasnickova",

year = "2007",

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journal = "Biochimica et Biophysica Acta-Molecular Basis of Disease",

issn = "0925-4439",

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Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase. / Kaiserova, H.; Simunek, T.; van der Vijgh, W.J. et al.
In: Biochimica et Biophysica Acta-Molecular Basis of Disease, Vol. 1772, No. 9, 01.01.2007, p. 1065-1074.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.

AU - Kaiserova, H.

AU - Simunek, T.

AU - van der Vijgh, W.J.

AU - Bast, A.

AU - Kvasnickova, E.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - AB - Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, anti

AB - AB - Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, anti

U2 - 10.1016/j.bbadis.2007.05.002

DO - 10.1016/j.bbadis.2007.05.002

M3 - Article

C2 - 17572073

SN - 0925-4439

VL - 1772

SP - 1065

EP - 1074

JO - Biochimica et Biophysica Acta-Molecular Basis of Disease

JF - Biochimica et Biophysica Acta-Molecular Basis of Disease

IS - 9

ER -