Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase.

H. Kaiserova, T. Simunek, W.J. van der Vijgh, A. Bast, E. Kvasnickova

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)

Abstract

AB - Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, anti
Original languageEnglish
Pages (from-to)1065-1074
JournalBiochimica et Biophysica Acta-Molecular Basis of Disease
Volume1772
Issue number9
DOIs
Publication statusPublished - 1 Jan 2007

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