First International Consensus on the diagnosis and management of fibromuscular dysplasia

Heather L. Gornik; Alexandre Persu; David Adlam; Lucas S. Aparicio; Michel Azizi; Marion Boulanger; Rosa Maria Bruno; Peter de Leeuw; Natalia Fendrikova-Mahlay; James Froehlich; Santhi K. Ganesh; Bruce H. Gray; Cathlin Jamison; Andrzej Januszewicz; Xavier Jeunemaitre; Daniella Kadian-Dodov; Esther S. H. Kim; Jason C. Kovacic; Pamela Mace; Alberto Morganti; Aditya Sharma; Andrew M. Southerland; Emmanuel Touze; Patricia van der Niepen; Jiguang Wang; Ido Weinberg; Scott Wilson; Jeffrey W. Olin; Pierre-Francois Plouin; European Society of Hypertension; Society for Vascular Medicine (SVM)

doi:10.1177/1358863X18821816

First International Consensus on the diagnosis and management of fibromuscular dysplasia

Heather L. Gornik^*, Alexandre Persu, David Adlam, Lucas S. Aparicio, Michel Azizi, Marion Boulanger, Rosa Maria Bruno, Peter de Leeuw, Natalia Fendrikova-Mahlay, James Froehlich, Santhi K. Ganesh, Bruce H. Gray, Cathlin Jamison, Andrzej Januszewicz, Xavier Jeunemaitre, Daniella Kadian-Dodov, Esther S. H. Kim, Jason C. Kovacic, Pamela Mace, Alberto MorgantiAditya Sharma, Andrew M. Southerland, Emmanuel Touze, Patricia van der Niepen, Jiguang Wang, Ido Weinberg, Scott Wilson, Jeffrey W. Olin, Pierre-Francois Plouin, European Society of Hypertension, Society for Vascular Medicine (SVM)

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.

Original language	English
Pages (from-to)	164-189
Number of pages	26
Journal	Vascular Medicine
Volume	24
Issue number	2
DOIs	https://doi.org/10.1177/1358863X18821816
Publication status	Published - Apr 2019

Keywords

ACUTE MYOCARDIAL-INFARCTION
AFRO-CARIBBEAN PATIENTS
BILATERAL BRACHIAL ARTERIES
CLINICAL-FEATURES
CORONARY-ARTERY DISSECTION
EHLERS-DANLOS-SYNDROME
GENOME-WIDE ASSOCIATION
RENAL-ARTERY
SUDDEN-DEATH
UNITED-STATES REGISTRY
aneurysm
cervical artery dissection
fibromuscular dysplasia (FMD)
percutaneous angioplasty
pressure gradients
renovascular hypertension
spontaneous coronary artery dissection
EXTRACORONARY VASCULAR ABNORMALITIES

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10.1177/1358863X18821816

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Gornik, H. L., Persu, A., Adlam, D., Aparicio, L. S., Azizi, M., Boulanger, M., Bruno, R. M., de Leeuw, P., Fendrikova-Mahlay, N., Froehlich, J., Ganesh, S. K., Gray, B. H., Jamison, C., Januszewicz, A., Jeunemaitre, X., Kadian-Dodov, D., Kim, E. S. H., Kovacic, J. C., Mace, P., ... Society for Vascular Medicine (SVM) (2019). First International Consensus on the diagnosis and management of fibromuscular dysplasia. Vascular Medicine, 24(2), 164-189. https://doi.org/10.1177/1358863X18821816

@article{d36ad9177f474985984734c796e0964b,

title = "First International Consensus on the diagnosis and management of fibromuscular dysplasia",

abstract = "This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.",

keywords = "ACUTE MYOCARDIAL-INFARCTION, AFRO-CARIBBEAN PATIENTS, BILATERAL BRACHIAL ARTERIES, CLINICAL-FEATURES, CORONARY-ARTERY DISSECTION, EHLERS-DANLOS-SYNDROME, GENOME-WIDE ASSOCIATION, RENAL-ARTERY, SUDDEN-DEATH, UNITED-STATES REGISTRY, aneurysm, cervical artery dissection, fibromuscular dysplasia (FMD), percutaneous angioplasty, pressure gradients, renovascular hypertension, spontaneous coronary artery dissection, EXTRACORONARY VASCULAR ABNORMALITIES",

author = "Gornik, {Heather L.} and Alexandre Persu and David Adlam and Aparicio, {Lucas S.} and Michel Azizi and Marion Boulanger and Bruno, {Rosa Maria} and {de Leeuw}, Peter and Natalia Fendrikova-Mahlay and James Froehlich and Ganesh, {Santhi K.} and Gray, {Bruce H.} and Cathlin Jamison and Andrzej Januszewicz and Xavier Jeunemaitre and Daniella Kadian-Dodov and Kim, {Esther S. H.} and Kovacic, {Jason C.} and Pamela Mace and Alberto Morganti and Aditya Sharma and Southerland, {Andrew M.} and Emmanuel Touze and {van der Niepen}, Patricia and Jiguang Wang and Ido Weinberg and Scott Wilson and Olin, {Jeffrey W.} and Pierre-Francois Plouin and {European Society of Hypertension} and {Society for Vascular Medicine (SVM)}",

note = "Funding Information: The authors have disclosed the following sources of funding for the research, authorship, and/or publication of this article. Dr. Froehlich has received funding to the Michigan Clinical Outcomes Research and Reporting Program (MCORRP) from the FMDSA to support the US Registry for FMD. Dr. Ganesh has received support from HL139672 and the Doris Duke Charitable Foundation. The other authors have no financial disclosures related to this article. Funding Information: The US Registry for FMD began enrolling patients in January 2009 at seven clinical centers in the continental United States and has subsequently expanded to 13 actively enrolling clinical centers. The US Registry is funded by the FMD Society of America (FMDSA) with centralized data coordination in a secure online platform by the University of Michigan Cardiovascular Outcomes Research and Reporting Program (www.med.umich.edu/ mcorrp/). As of February 2018, the US Registry has enrolled nearly 2000 patients and has had seven publications in peer-reviewed journals.1,3,4,11,41,59,60Some clinical centers in the US Registry enroll pediatric as well as adult FMD patients. Funding Information: The authors acknowledge Dr Christopher Bajzer (Cleveland Clinic), Dr Robert Lookstein (Mount Sinai Medical Center), Dr Alan Matsumoto (University of Virginia), and Dr Sanjay Misra (Mayo Clinic) for their insights on renal FMD and prior participation in working groups of the International FMD Research Network focused on renal angiography and angioplasty, which formed a foundation for Table 6. The authors thank Ms Marianne Khoury (Cleveland Clinic) for her assistance in coordinating and formatting the manuscript; Dr Laurent Toubiana (INSERM UMRS 1142 LIMICS/IRSAN, Paris, France) and Dr Silvia Di Monaco (Cliniques Universitaires Saint-Luc, Brussels, Belgium/AOU Citt? della Salute e della Scienza, Turin, Italy) for data extraction and analysis of the European FMD Registry (Tables 4 and 5); and Dr Xiaokui Gu (University of Michigan) for data extraction and analysis of the US Registry for FMD (Tables 4 and 5). They also wish to acknowledge Dr Pasquale Scoppettuolo (H?pital Erasme, Brussels, Belgium) for providing panel C of Figure 1, Dr Robert Lookstein for providing panels A?C of Figure 2, Professor Patrick Chenu and Professor Frank Hammer (Cliniques Universitaires Saint-Luc, Brussels, Belgium) for panels A and C of Figure 3, respectively, and Dr Lucas Aparicio (Hospital Italiano, Buenos Aires, Argentina) for panel B of the same figure. Dr David Adlam wishes to acknowledge the ESC-ACCA SCAD study group and the BeatSCAD organization. Finally, Mrs Cathlin Jamison wishes to acknowledge Dr V?ronique Godin (FMD-Be) for fruitful discussion and contribution to the section on the role of patient associations. The authors thank all of the patients who have participated in international registries and research studies of FMD, CeAD, and SCAD, as these studies have greatly helped to advance our understanding of these diseases. The authors have disclosed the following sources of funding for the research, authorship, and/or publication of this article. Dr. Froehlich has received funding to the Michigan Clinical Outcomes Research and Reporting Program (MCORRP) from the FMDSA to support the US Registry for FMD. Dr. Ganesh has received support from HL139672 and the Doris Duke Charitable Foundation. The other authors have no financial disclosures related to this article. Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

month = apr,

doi = "10.1177/1358863X18821816",

language = "English",

volume = "24",

pages = "164--189",

journal = "Vascular Medicine",

issn = "1358-863X",

publisher = "SAGE Publications Ltd",

number = "2",

}

Gornik, HL, Persu, A, Adlam, D, Aparicio, LS, Azizi, M, Boulanger, M, Bruno, RM, de Leeuw, P, Fendrikova-Mahlay, N, Froehlich, J, Ganesh, SK, Gray, BH, Jamison, C, Januszewicz, A, Jeunemaitre, X, Kadian-Dodov, D, Kim, ESH, Kovacic, JC, Mace, P, Morganti, A, Sharma, A, Southerland, AM, Touze, E, van der Niepen, P, Wang, J, Weinberg, I, Wilson, S, Olin, JW, Plouin, P-F, European Society of Hypertension & Society for Vascular Medicine (SVM) 2019, 'First International Consensus on the diagnosis and management of fibromuscular dysplasia', Vascular Medicine, vol. 24, no. 2, pp. 164-189. https://doi.org/10.1177/1358863X18821816

TY - JOUR

T1 - First International Consensus on the diagnosis and management of fibromuscular dysplasia

AU - Gornik, Heather L.

AU - Persu, Alexandre

AU - Adlam, David

AU - Aparicio, Lucas S.

AU - Azizi, Michel

AU - Boulanger, Marion

AU - Bruno, Rosa Maria

AU - de Leeuw, Peter

AU - Fendrikova-Mahlay, Natalia

AU - Froehlich, James

AU - Ganesh, Santhi K.

AU - Gray, Bruce H.

AU - Jamison, Cathlin

AU - Januszewicz, Andrzej

AU - Jeunemaitre, Xavier

AU - Kadian-Dodov, Daniella

AU - Kim, Esther S. H.

AU - Kovacic, Jason C.

AU - Mace, Pamela

AU - Morganti, Alberto

AU - Sharma, Aditya

AU - Southerland, Andrew M.

AU - Touze, Emmanuel

AU - van der Niepen, Patricia

AU - Wang, Jiguang

AU - Weinberg, Ido

AU - Wilson, Scott

AU - Olin, Jeffrey W.

AU - Plouin, Pierre-Francois

AU - European Society of Hypertension

AU - Society for Vascular Medicine (SVM)

N1 - Funding Information: The authors have disclosed the following sources of funding for the research, authorship, and/or publication of this article. Dr. Froehlich has received funding to the Michigan Clinical Outcomes Research and Reporting Program (MCORRP) from the FMDSA to support the US Registry for FMD. Dr. Ganesh has received support from HL139672 and the Doris Duke Charitable Foundation. The other authors have no financial disclosures related to this article. Funding Information: The US Registry for FMD began enrolling patients in January 2009 at seven clinical centers in the continental United States and has subsequently expanded to 13 actively enrolling clinical centers. The US Registry is funded by the FMD Society of America (FMDSA) with centralized data coordination in a secure online platform by the University of Michigan Cardiovascular Outcomes Research and Reporting Program (www.med.umich.edu/ mcorrp/). As of February 2018, the US Registry has enrolled nearly 2000 patients and has had seven publications in peer-reviewed journals.1,3,4,11,41,59,60Some clinical centers in the US Registry enroll pediatric as well as adult FMD patients. Funding Information: The authors acknowledge Dr Christopher Bajzer (Cleveland Clinic), Dr Robert Lookstein (Mount Sinai Medical Center), Dr Alan Matsumoto (University of Virginia), and Dr Sanjay Misra (Mayo Clinic) for their insights on renal FMD and prior participation in working groups of the International FMD Research Network focused on renal angiography and angioplasty, which formed a foundation for Table 6. The authors thank Ms Marianne Khoury (Cleveland Clinic) for her assistance in coordinating and formatting the manuscript; Dr Laurent Toubiana (INSERM UMRS 1142 LIMICS/IRSAN, Paris, France) and Dr Silvia Di Monaco (Cliniques Universitaires Saint-Luc, Brussels, Belgium/AOU Citt? della Salute e della Scienza, Turin, Italy) for data extraction and analysis of the European FMD Registry (Tables 4 and 5); and Dr Xiaokui Gu (University of Michigan) for data extraction and analysis of the US Registry for FMD (Tables 4 and 5). They also wish to acknowledge Dr Pasquale Scoppettuolo (H?pital Erasme, Brussels, Belgium) for providing panel C of Figure 1, Dr Robert Lookstein for providing panels A?C of Figure 2, Professor Patrick Chenu and Professor Frank Hammer (Cliniques Universitaires Saint-Luc, Brussels, Belgium) for panels A and C of Figure 3, respectively, and Dr Lucas Aparicio (Hospital Italiano, Buenos Aires, Argentina) for panel B of the same figure. Dr David Adlam wishes to acknowledge the ESC-ACCA SCAD study group and the BeatSCAD organization. Finally, Mrs Cathlin Jamison wishes to acknowledge Dr V?ronique Godin (FMD-Be) for fruitful discussion and contribution to the section on the role of patient associations. The authors thank all of the patients who have participated in international registries and research studies of FMD, CeAD, and SCAD, as these studies have greatly helped to advance our understanding of these diseases. The authors have disclosed the following sources of funding for the research, authorship, and/or publication of this article. Dr. Froehlich has received funding to the Michigan Clinical Outcomes Research and Reporting Program (MCORRP) from the FMDSA to support the US Registry for FMD. Dr. Ganesh has received support from HL139672 and the Doris Duke Charitable Foundation. The other authors have no financial disclosures related to this article. Publisher Copyright: © The Author(s) 2019.

PY - 2019/4

Y1 - 2019/4

N2 - This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.

AB - This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group 'Hypertension and the Kidney' of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.

KW - ACUTE MYOCARDIAL-INFARCTION

KW - AFRO-CARIBBEAN PATIENTS

KW - BILATERAL BRACHIAL ARTERIES

KW - CLINICAL-FEATURES

KW - CORONARY-ARTERY DISSECTION

KW - EHLERS-DANLOS-SYNDROME

KW - GENOME-WIDE ASSOCIATION

KW - RENAL-ARTERY

KW - SUDDEN-DEATH

KW - UNITED-STATES REGISTRY

KW - aneurysm

KW - cervical artery dissection

KW - fibromuscular dysplasia (FMD)

KW - percutaneous angioplasty

KW - pressure gradients

KW - renovascular hypertension

KW - spontaneous coronary artery dissection

KW - EXTRACORONARY VASCULAR ABNORMALITIES

U2 - 10.1177/1358863X18821816

DO - 10.1177/1358863X18821816

M3 - Article

C2 - 30648921

SN - 1358-863X

VL - 24

SP - 164

EP - 189

JO - Vascular Medicine

JF - Vascular Medicine

IS - 2

ER -

First International Consensus on the diagnosis and management of fibromuscular dysplasia

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Keywords

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