Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

D. Dreymueller; K. Theodorou; M. Donners; A. Ludwig

doi:10.1155/2017/9621724

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

D. Dreymueller^*, K. Theodorou, M. Donners^*, A. Ludwig

^*Corresponding author for this work

Pathologie

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesionmolecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.

Original language	English
Article number	9621724
Number of pages	22
Journal	Mediators of Inflammation
Volume	2017
DOIs	https://doi.org/10.1155/2017/9621724
Publication status	Published - 2017

Keywords

NECROSIS-FACTOR-ALPHA
ENDOTHELIAL GROWTH-FACTOR
FIBROBLAST-LIKE SYNOVIOCYTES
OVARIAN-CARCINOMA CELLS
PANCREATIC-CANCER CELLS
CENTRAL-NERVOUS-SYSTEM
C-TERMINAL FRAGMENT
TNF-ALPHA
CONVERTING-ENZYME
RHEUMATOID-ARTHRITIS

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10.1155/2017/9621724Licence: CC BY

Cite this

@article{521a457476af454ca01595ec022817ce,

title = "Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases",

abstract = "Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesionmolecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.",

keywords = "NECROSIS-FACTOR-ALPHA, ENDOTHELIAL GROWTH-FACTOR, FIBROBLAST-LIKE SYNOVIOCYTES, OVARIAN-CARCINOMA CELLS, PANCREATIC-CANCER CELLS, CENTRAL-NERVOUS-SYSTEM, C-TERMINAL FRAGMENT, TNF-ALPHA, CONVERTING-ENZYME, RHEUMATOID-ARTHRITIS",

author = "D. Dreymueller and K. Theodorou and M. Donners and A. Ludwig",

year = "2017",

doi = "10.1155/2017/9621724",

language = "English",

volume = "2017",

journal = "Mediators of Inflammation",

issn = "0962-9351",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

AU - Dreymueller, D.

AU - Theodorou, K.

AU - Donners, M.

AU - Ludwig, A.

PY - 2017

Y1 - 2017

N2 - Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesionmolecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.

AB - Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesionmolecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.

KW - NECROSIS-FACTOR-ALPHA

KW - ENDOTHELIAL GROWTH-FACTOR

KW - FIBROBLAST-LIKE SYNOVIOCYTES

KW - OVARIAN-CARCINOMA CELLS

KW - PANCREATIC-CANCER CELLS

KW - CENTRAL-NERVOUS-SYSTEM

KW - C-TERMINAL FRAGMENT

KW - TNF-ALPHA

KW - CONVERTING-ENZYME

KW - RHEUMATOID-ARTHRITIS

U2 - 10.1155/2017/9621724

DO - 10.1155/2017/9621724

M3 - (Systematic) Review article

C2 - 28260841

SN - 0962-9351

VL - 2017

JO - Mediators of Inflammation

JF - Mediators of Inflammation

M1 - 9621724

ER -