Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

D. Dreymueller*, K. Theodorou, M. Donners*, A. Ludwig

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

15 Citations (Web of Science)

Abstract

Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesionmolecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.

Original languageEnglish
Article number9621724
Number of pages22
JournalMediators of Inflammation
Volume2017
DOIs
Publication statusPublished - 2017

Keywords

  • NECROSIS-FACTOR-ALPHA
  • ENDOTHELIAL GROWTH-FACTOR
  • FIBROBLAST-LIKE SYNOVIOCYTES
  • OVARIAN-CARCINOMA CELLS
  • PANCREATIC-CANCER CELLS
  • CENTRAL-NERVOUS-SYSTEM
  • C-TERMINAL FRAGMENT
  • TNF-ALPHA
  • CONVERTING-ENZYME
  • RHEUMATOID-ARTHRITIS

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