Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen, Siddhartha Kar, Karen A. Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P. Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M. Rosario AlonsoIrene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Adalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Bernd Auber, Paul L. Auer, Jacopo Azzollini, Judith Balmana, Rosa B. Barkardottir, Daniel Barrowdale, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Katarzyna Bialkowska, Amie M. Blanco, Carl Blomqvist, William Blot, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Ake Borg, Kristin Bosse, Hiltrud Brauch, Hermann Brenner, Maaike de Boer, Encarna Gomez Garcia, Marinus Blok, GEMO Study Collaborators, EMBRACE Collaborators, KConFab Investigators, HEBON Investigators, ABCTB Investigators

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)56–73
Number of pages25
JournalNature Genetics
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • GENOME-WIDE ASSOCIATION
  • COMPREHENSIVE MOLECULAR PORTRAITS
  • ESTROGEN-RECEPTOR
  • INTEGRATIVE ANALYSIS
  • FUNCTIONAL VARIANTS
  • SUSCEPTIBILITY LOCI
  • PROTEIN FUNCTION
  • CHROMATIN
  • ENHANCER
  • REVEALS

Cite this

Fachal, L., Aschard, H., Beesley, J., Barnes, D. R., Allen, J., Kar, S., Pooley, K. A., Dennis, J., Michailidou, K., Turman, C., Soucy, P., Lemacon, A., Lush, M., Tyrer, J. P., Ghoussaini, M., Marjaneh, M. M., Jiang, X., Agata, S., Aittomaki, K., ... ABCTB Investigators (2020). Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nature Genetics, 52(1), 56–73. https://doi.org/10.1038/s41588-019-0537-1