Fibrosis Reduces the Coincidence of Repetitive Activations Patterns between the Coronary Sinus and Atrial Regions in Simulated Atrial Fibrillation

Margot van Montfoort, Victor Gonçalves Marques, Ozan Özgül, Ali Gharaviri2, Simone Pezzuto, Angelo Auricchio, Pietro Bonizzi, Ulrich Schotten, Stef Zeemering*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

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Abstract

Repetitive Atrial Activation Patterns (RAAPs) detected in the coronary sinus (CS) during atrial fibrillation (AF) may represent a reference to construct composite maps of coincident local RAAPs elsewhere in the atria, potentially improving the identification of AF drivers. RAAP coincidence may however depend on AF complexity and may be affected by structural remodeling. Using computer simulations, we investigated coincidence and coupling of RAAPs in the CS and other regions in the atria, in the absence and presence of fibrosis. In our models, the CS displayed highly repetitive behavior unaffected by fibrosis. RAAP coincidence and coupling of other regions in the atria with the CS was high in the absence of fibrosis, but significantly decreased in the presence of fibrosis, most notably in the left atrium. In coincident RAAPs in the CS and atrial regions, quantification of the degree of RAAP coupling is required to provide further confirmation of the validity of employing CS electrograms as a reference for composite RAAPs maps.

Original languageEnglish
Title of host publication2022 Computing in Cardiology (CinC)
Number of pages4
Volume49
DOIs
Publication statusPublished - 2022
Event49th Computing in Cardiology Conference 2022 - Tampere Hall, Tampere, Finland
Duration: 4 Sept 20227 Sept 2022
Conference number: 49
https://events.tuni.fi/cinc2022/

Conference

Conference49th Computing in Cardiology Conference 2022
Abbreviated titleCinC 2022
Country/TerritoryFinland
CityTampere
Period4/09/227/09/22
Internet address

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