Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1-and Combination Antiretroviral Therapy-Exposed Infants

Johannes C. Schoeman, Gontse P. Moutloatse, Amy C. Harms, Rob J. Vreeken, Henriette J. Scherpbier, Liesbeth Van Leeuwen, Taco W. Kuijpers, Carools J. Reinecke, Ruud Berger, Thomas Hankemeier, Madeleine J. Bunders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)436-446
Number of pages11
JournalJournal of Infectious Diseases
Volume216
Issue number4
DOIs
Publication statusPublished - 15 Aug 2017

Keywords

  • immune metabolism
  • fetal development
  • HIV-1
  • metabolomics
  • antiretroviral therapy
  • PERSISTENT MITOCHONDRIAL DYSFUNCTION
  • REVERSE-TRANSCRIPTASE INHIBITORS
  • TO-CHILD TRANSMISSION
  • IN-UTERO
  • PERINATAL EXPOSURE
  • UNINFECTED INFANTS
  • PATAS MONKEYS
  • CORD BLOOD
  • PREGNANCY
  • WOMEN

Cite this

Schoeman, J. C., Moutloatse, G. P., Harms, A. C., Vreeken, R. J., Scherpbier, H. J., Van Leeuwen, L., Kuijpers, T. W., Reinecke, C. J., Berger, R., Hankemeier, T., & Bunders, M. J. (2017). Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1-and Combination Antiretroviral Therapy-Exposed Infants. Journal of Infectious Diseases, 216(4), 436-446. https://doi.org/10.1093/infdis/jix291