Feasibility of a Cognitive Training Game in Parkinson's Disease: The Randomized Parkin'Play Study

Sjors C. F. van de Weijer; Annelien A. Duits; Bastiaan R. Bloem; Nienke M. de Vries; Roy P. C. Kessels; Sebastian Kohler; Gerrit Tissingh; Mark L. Kuijf

doi:10.1159/000509685

Feasibility of a Cognitive Training Game in Parkinson's Disease: The Randomized Parkin'Play Study

Sjors C. F. van de Weijer^*, Annelien A. Duits, Bastiaan R. Bloem, Nienke M. de Vries, Roy P. C. Kessels, Sebastian Kohler, Gerrit Tissingh, Mark L. Kuijf

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson's disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.

Original language	English
Pages (from-to)	426-432
Number of pages	7
Journal	European Neurology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1159/000509685
Publication status	Published - Oct 2020

Keywords

Cognition
Video games
Feasibility study
Parkinson's disease
TRIAL

Access to Document

10.1159/000509685Licence: CC BY-NC-ND

Cite this

@article{0c8d1a3510904bdbaa9c70f15a2a3aa6,

title = "Feasibility of a Cognitive Training Game in Parkinson's Disease: The Randomized Parkin'Play Study",

abstract = "Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson's disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.",

keywords = "Cognition, Video games, Feasibility study, Parkinson's disease, TRIAL",

author = "{van de Weijer}, {Sjors C. F.} and Duits, {Annelien A.} and Bloem, {Bastiaan R.} and {de Vries}, {Nienke M.} and Kessels, {Roy P. C.} and Sebastian Kohler and Gerrit Tissingh and Kuijf, {Mark L.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) Published by S. Karger AG, Basel.",

year = "2020",

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doi = "10.1159/000509685",

language = "English",

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T2 - The Randomized Parkin'Play Study

AU - van de Weijer, Sjors C. F.

AU - Duits, Annelien A.

AU - Bloem, Bastiaan R.

AU - de Vries, Nienke M.

AU - Kessels, Roy P. C.

AU - Kohler, Sebastian

AU - Tissingh, Gerrit

AU - Kuijf, Mark L.

PY - 2020/10

Y1 - 2020/10

N2 - Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson's disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.

AB - Cognitive training (CT) shows modest positive effects on cognitive function in patients with Parkinson's disease (PD). Gamification may enhance adherence to traditional CT, but this has not been studied yet. Here, we investigated the feasibility of a gamified CT. We performed a randomized controlled trial including PD patients with mild cognitive impairment. Participants were randomly allocated to a 12-week home-based gamified CT intervention or waiting-list control group. Assessments were performed at baseline and at weeks 12 and 24. Forty-one patients were included (21 intervention and 20 waiting-list controls). Sixty-three percent of the intervention group trained >50% of the recommended sessions, while 81% voluntarily continued training after 12 weeks. After 24 weeks, 87.5% graded the game to be satisfactory. Global cognition scores improved after 24 weeks. Home-based gamified CT shows acceptable feasibility in patients with PD, and we observed preliminary indications for efficacy. Larger trials are needed to establish this efficacy.

KW - Cognition

KW - Video games

KW - Feasibility study

KW - Parkinson's disease

KW - TRIAL

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