TY - JOUR
T1 - Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis
AU - Bannier, Michiel A. G. E.
AU - van de Kant, Kim D. G.
AU - Jobsis, Quirijn
AU - Dompeling, Edward
N1 - Publisher Copyright:
© 2019 IOP Publishing Ltd.
PY - 2019/7
Y1 - 2019/7
N2 - The measurement of volatile organic compounds (VOCs) in exhaled breath is a promising tool for diagnosing and monitoring various lung diseases in children. Gas chromatography mass spectrometry (GC-MS) analysis is a frequently used standard technique for VOCs analysis. However, as GC-MS is an expensive and time-consuming technique, hand-held devices or electronic noses have been developed. Recently, the Aeonose was introduced as an easy-to-use hand-held eNose capable of pointof-care testing. Although first results using this eNose in adults are promising, studies in children are lacking. We therefore performed a cross-sectional study in 55 children and adolescents >= 6 years of age (20 children with moderate to severe asthma, 13 children with CF, and 22 healthy controls). The feasibility of the Aeonose was high (>98% successful measurements). The diagnostic accuracy was high for discriminating asthma from CF (Area Under the Receiver Operating Characteristic Curve [AUC] 0.90 [95% Confidence Interval 0.78-1.00] sensitivity 89% [65%-98%], specificity 77% [46%94%]), and for the distinction between CF and healthy controls (AUC 0.87 [0.74-1.00], sensitivity 85% [54%-97%], specificity 77% [54%-91%]). However, the diagnostic accuracy for the discrimination between asthma and healthy controls was modest (AUC 0.79 [0.63-0.94], sensitivity 74% [49%90%], specificity 91% [69%-98%]). This is the first study to report test results of the Aeonose in children and adolescents 6 years. This eNose showed a high feasibility with modest to good diagnostic accuracies in asthma and CF.
AB - The measurement of volatile organic compounds (VOCs) in exhaled breath is a promising tool for diagnosing and monitoring various lung diseases in children. Gas chromatography mass spectrometry (GC-MS) analysis is a frequently used standard technique for VOCs analysis. However, as GC-MS is an expensive and time-consuming technique, hand-held devices or electronic noses have been developed. Recently, the Aeonose was introduced as an easy-to-use hand-held eNose capable of pointof-care testing. Although first results using this eNose in adults are promising, studies in children are lacking. We therefore performed a cross-sectional study in 55 children and adolescents >= 6 years of age (20 children with moderate to severe asthma, 13 children with CF, and 22 healthy controls). The feasibility of the Aeonose was high (>98% successful measurements). The diagnostic accuracy was high for discriminating asthma from CF (Area Under the Receiver Operating Characteristic Curve [AUC] 0.90 [95% Confidence Interval 0.78-1.00] sensitivity 89% [65%-98%], specificity 77% [46%94%]), and for the distinction between CF and healthy controls (AUC 0.87 [0.74-1.00], sensitivity 85% [54%-97%], specificity 77% [54%-91%]). However, the diagnostic accuracy for the discrimination between asthma and healthy controls was modest (AUC 0.79 [0.63-0.94], sensitivity 74% [49%90%], specificity 91% [69%-98%]). This is the first study to report test results of the Aeonose in children and adolescents 6 years. This eNose showed a high feasibility with modest to good diagnostic accuracies in asthma and CF.
KW - asthma
KW - cystic fibrosis
KW - electronic nose
KW - exhaled breath
KW - volatile organic compounds
KW - children
KW - VOLATILE ORGANIC-COMPOUNDS
KW - DISCRIMINATION
U2 - 10.1088/1752-7163/aae158
DO - 10.1088/1752-7163/aae158
M3 - Article
C2 - 30213921
SN - 1752-7155
VL - 13
JO - Journal of Breath Research
JF - Journal of Breath Research
IS - 3
M1 - 036009
ER -