Fast periodic stimulation (FPS): a highly effective approach in fMRI brain mapping

Xiaoqing Gao, Francesco Gentile, Bruno Rossion

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Defining the neural basis of perceptual categorization in a rapidly changing natural environment with low-temporal resolution methods such as functional magnetic resonance imaging (fMRI) is challenging. Here, we present a novel fast periodic stimulation (FPS)-fMRI approach to define face-selective brain regions with natural images. Human observers are presented with a dynamic stream of widely variable natural object images alternating at a fast rate (6 images/s). Every 9 s, a short burst of variable face images contrasting with object images in pairs induces an objective face-selective neural response at 0.111 Hz. A model-free Fourier analysis achieves a twofold increase in signal-to-noise ratio compared to a conventional block-design approach with identical stimuli and scanning duration, allowing to derive a comprehensive map of face-selective areas in the ventral occipito-temporal cortex, including the anterior temporal lobe (ATL), in all individual brains. Critically, periodicity of the desired category contrast and random variability among widely diverse images effectively eliminates the contribution of low-level visual cues, and lead to the highest values (80-90%) of test-retest reliability in the spatial activation map yet reported in imaging higher level visual functions. FPS-fMRI opens a new avenue for understanding brain function with low-temporal resolution methods.

Original languageEnglish
Pages (from-to)2433-2454
Number of pages22
JournalBrain Structure & Function
Volume223
Issue number5
DOIs
Publication statusPublished - Jun 2018

Keywords

  • fMRI
  • Brain mapping
  • Frequency tagging
  • Visual categorization
  • Face
  • VENTRAL TEMPORAL CORTEX
  • FACE-PROCESSING NETWORK
  • FUNCTIONAL LOCALIZERS
  • SELECTIVE REGIONS
  • NEURAL RESPONSE
  • VISUAL PATHWAY
  • FACIAL IDENTITY
  • SENSITIVE AREAS
  • FUSIFORM GYRUS
  • ALPHA-ACTIVITY
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Young Adult
  • Brain/diagnostic imaging
  • Adult
  • Female
  • Periodicity
  • Image Processing, Computer-Assisted
  • Brain Mapping
  • Pattern Recognition, Visual
  • Photic Stimulation
  • Oxygen/blood

Cite this

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title = "Fast periodic stimulation (FPS): a highly effective approach in fMRI brain mapping",
abstract = "Defining the neural basis of perceptual categorization in a rapidly changing natural environment with low-temporal resolution methods such as functional magnetic resonance imaging (fMRI) is challenging. Here, we present a novel fast periodic stimulation (FPS)-fMRI approach to define face-selective brain regions with natural images. Human observers are presented with a dynamic stream of widely variable natural object images alternating at a fast rate (6 images/s). Every 9 s, a short burst of variable face images contrasting with object images in pairs induces an objective face-selective neural response at 0.111 Hz. A model-free Fourier analysis achieves a twofold increase in signal-to-noise ratio compared to a conventional block-design approach with identical stimuli and scanning duration, allowing to derive a comprehensive map of face-selective areas in the ventral occipito-temporal cortex, including the anterior temporal lobe (ATL), in all individual brains. Critically, periodicity of the desired category contrast and random variability among widely diverse images effectively eliminates the contribution of low-level visual cues, and lead to the highest values (80-90{\%}) of test-retest reliability in the spatial activation map yet reported in imaging higher level visual functions. FPS-fMRI opens a new avenue for understanding brain function with low-temporal resolution methods.",
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author = "Xiaoqing Gao and Francesco Gentile and Bruno Rossion",
year = "2018",
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doi = "10.1007/s00429-018-1630-4",
language = "English",
volume = "223",
pages = "2433--2454",
journal = "Brain Structure & Function",
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Fast periodic stimulation (FPS) : a highly effective approach in fMRI brain mapping. / Gao, Xiaoqing; Gentile, Francesco; Rossion, Bruno.

In: Brain Structure & Function, Vol. 223, No. 5, 06.2018, p. 2433-2454.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fast periodic stimulation (FPS)

T2 - a highly effective approach in fMRI brain mapping

AU - Gao, Xiaoqing

AU - Gentile, Francesco

AU - Rossion, Bruno

PY - 2018/6

Y1 - 2018/6

N2 - Defining the neural basis of perceptual categorization in a rapidly changing natural environment with low-temporal resolution methods such as functional magnetic resonance imaging (fMRI) is challenging. Here, we present a novel fast periodic stimulation (FPS)-fMRI approach to define face-selective brain regions with natural images. Human observers are presented with a dynamic stream of widely variable natural object images alternating at a fast rate (6 images/s). Every 9 s, a short burst of variable face images contrasting with object images in pairs induces an objective face-selective neural response at 0.111 Hz. A model-free Fourier analysis achieves a twofold increase in signal-to-noise ratio compared to a conventional block-design approach with identical stimuli and scanning duration, allowing to derive a comprehensive map of face-selective areas in the ventral occipito-temporal cortex, including the anterior temporal lobe (ATL), in all individual brains. Critically, periodicity of the desired category contrast and random variability among widely diverse images effectively eliminates the contribution of low-level visual cues, and lead to the highest values (80-90%) of test-retest reliability in the spatial activation map yet reported in imaging higher level visual functions. FPS-fMRI opens a new avenue for understanding brain function with low-temporal resolution methods.

AB - Defining the neural basis of perceptual categorization in a rapidly changing natural environment with low-temporal resolution methods such as functional magnetic resonance imaging (fMRI) is challenging. Here, we present a novel fast periodic stimulation (FPS)-fMRI approach to define face-selective brain regions with natural images. Human observers are presented with a dynamic stream of widely variable natural object images alternating at a fast rate (6 images/s). Every 9 s, a short burst of variable face images contrasting with object images in pairs induces an objective face-selective neural response at 0.111 Hz. A model-free Fourier analysis achieves a twofold increase in signal-to-noise ratio compared to a conventional block-design approach with identical stimuli and scanning duration, allowing to derive a comprehensive map of face-selective areas in the ventral occipito-temporal cortex, including the anterior temporal lobe (ATL), in all individual brains. Critically, periodicity of the desired category contrast and random variability among widely diverse images effectively eliminates the contribution of low-level visual cues, and lead to the highest values (80-90%) of test-retest reliability in the spatial activation map yet reported in imaging higher level visual functions. FPS-fMRI opens a new avenue for understanding brain function with low-temporal resolution methods.

KW - fMRI

KW - Brain mapping

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KW - VENTRAL TEMPORAL CORTEX

KW - FACE-PROCESSING NETWORK

KW - FUNCTIONAL LOCALIZERS

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KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Young Adult

KW - Brain/diagnostic imaging

KW - Adult

KW - Female

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KW - Image Processing, Computer-Assisted

KW - Brain Mapping

KW - Pattern Recognition, Visual

KW - Photic Stimulation

KW - Oxygen/blood

U2 - 10.1007/s00429-018-1630-4

DO - 10.1007/s00429-018-1630-4

M3 - Article

C2 - 29502144

VL - 223

SP - 2433

EP - 2454

JO - Brain Structure & Function

JF - Brain Structure & Function

SN - 1863-2653

IS - 5

ER -