Fast accurate MR thermometry using phase referenced asymmetric spin-echo EPI at high field

M.N. Streicher*, A. Schäfer, D.V. Ivanov, D.K. Müller, A. Amadon, E. Reimer, L. Huber, B. Dhital, D. Rivera, C. Kögler, R. Trampel, A. Pampel, R. Turner

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


PurposeA novel highly accurate method for MR thermometry, effective at high field, is introduced and validated, which corrects for slow and fast field fluctuations by means of reference images.

MethodsAn asymmetric spin-echo echo planar imaging sequence was made frequency-selective to water or a reference substance by controlling the slice-select gradient polarity and the duration of the excitation and refocusing radiofrequency pulses. Images were acquired pairwise, and the temperature-sensitive water images were corrected for field fluctuations using the reference images. In a phantom radiofrequency heating experiment, dissolved dimethyl sulfoxide was used as a reference substance. Temperature stability was tested in vivo on the human brain, referenced using subcutaneous scalp fat. Water and fat phase images were acquired only 50 ms apart. Bloch simulations validated the frequency selection accuracy.

ResultsAsymmetric spin-echo imaging using a simple frequency selection method provides highly accurate referenced MR thermometry in phantoms and in vivo at 7 T. Effects of field fluctuations caused by field drift, breathing, and heart beat were corrected. The technique is highly robust against B-1 inhomogeneities.

ConclusionFrequency selection using gradient-reversal can enable fast accurate referenced in vivo MR thermometry, assisting thermal characterization of radiofrequency coils and possibly in vivo SAR monitoring. Magn Reson Med 71:524-533, 2014. 

Original languageEnglish
Pages (from-to)524-533
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number2
Publication statusPublished - Feb 2014


  • FAT
  • MR thermometry
  • NMR
  • asymmetric
  • fat
  • proton resonance frequency shift
  • referenced
  • spin-echo


Dive into the research topics of 'Fast accurate MR thermometry using phase referenced asymmetric spin-echo EPI at high field'. Together they form a unique fingerprint.

Cite this