Farmacogenetica bij de behandeling van tabaksverslaving [Pharmacogenetics in the treatment of tobacco addiction]

M. Quaak; F.J. van Schooten; C.P. van Schayck

Farmacogenetica bij de behandeling van tabaksverslaving [Pharmacogenetics in the treatment of tobacco addiction]

M. Quaak, F.J. van Schooten, C.P. van Schayck

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies. AIM: To provide an overview of the developments on the pharmacogenetics of the treatment of tobacco addiction. METHOD: Review article describing the biological processes associated with tobacco addiction, and the influence of genetic variants on smoking behavior and the efficacy of smoking cessation therapies. RESULTS: Several (combinations of) genetic variants in smoking-related genes influence nicotine dependence. Moreover, several genetic variants in smoking- and treatment-related genes seem to influence the efficacy of smoking cessation therapies which are distinctive for the different forms of pharmacotherapy, especially when they have a different mechanism-of-action. CONCLUSION: Much progress has been made in unraveling the (pharmaco)genetics of tobacco addiction, but much still remains to be done before genetically tailored smoking cessation therapy can be implemented in clinical practice.

Original language	English
Pages (from-to)	891-898
Journal	Tijdschrift voor Psychiatrie
Volume	55
Issue number	11
Publication status	Published - 1 Jan 2013

Access to Document

http://www.ncbi.nlm.nih.gov/pubmed/24242150

Cite this

@article{727d28dc77e744cca0eb1ce7d2332159,

title = "Farmacogenetica bij de behandeling van tabaksverslaving [Pharmacogenetics in the treatment of tobacco addiction]",

abstract = "BACKGROUND: Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies. AIM: To provide an overview of the developments on the pharmacogenetics of the treatment of tobacco addiction. METHOD: Review article describing the biological processes associated with tobacco addiction, and the influence of genetic variants on smoking behavior and the efficacy of smoking cessation therapies. RESULTS: Several (combinations of) genetic variants in smoking-related genes influence nicotine dependence. Moreover, several genetic variants in smoking- and treatment-related genes seem to influence the efficacy of smoking cessation therapies which are distinctive for the different forms of pharmacotherapy, especially when they have a different mechanism-of-action. CONCLUSION: Much progress has been made in unraveling the (pharmaco)genetics of tobacco addiction, but much still remains to be done before genetically tailored smoking cessation therapy can be implemented in clinical practice.",

author = "M. Quaak and {van Schooten}, F.J. and {van Schayck}, C.P.",

year = "2013",

month = jan,

day = "1",

language = "English",

volume = "55",

pages = "891--898",

journal = "Tijdschrift voor Psychiatrie",

issn = "0303-7339",

publisher = "Uitgeverij Boom",

number = "11",

}

TY - JOUR

T1 - Farmacogenetica bij de behandeling van tabaksverslaving [Pharmacogenetics in the treatment of tobacco addiction]

AU - Quaak, M.

AU - van Schooten, F.J.

AU - van Schayck, C.P.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies. AIM: To provide an overview of the developments on the pharmacogenetics of the treatment of tobacco addiction. METHOD: Review article describing the biological processes associated with tobacco addiction, and the influence of genetic variants on smoking behavior and the efficacy of smoking cessation therapies. RESULTS: Several (combinations of) genetic variants in smoking-related genes influence nicotine dependence. Moreover, several genetic variants in smoking- and treatment-related genes seem to influence the efficacy of smoking cessation therapies which are distinctive for the different forms of pharmacotherapy, especially when they have a different mechanism-of-action. CONCLUSION: Much progress has been made in unraveling the (pharmaco)genetics of tobacco addiction, but much still remains to be done before genetically tailored smoking cessation therapy can be implemented in clinical practice.

AB - BACKGROUND: Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies. AIM: To provide an overview of the developments on the pharmacogenetics of the treatment of tobacco addiction. METHOD: Review article describing the biological processes associated with tobacco addiction, and the influence of genetic variants on smoking behavior and the efficacy of smoking cessation therapies. RESULTS: Several (combinations of) genetic variants in smoking-related genes influence nicotine dependence. Moreover, several genetic variants in smoking- and treatment-related genes seem to influence the efficacy of smoking cessation therapies which are distinctive for the different forms of pharmacotherapy, especially when they have a different mechanism-of-action. CONCLUSION: Much progress has been made in unraveling the (pharmaco)genetics of tobacco addiction, but much still remains to be done before genetically tailored smoking cessation therapy can be implemented in clinical practice.

M3 - Article

SN - 0303-7339

VL - 55

SP - 891

EP - 898

JO - Tijdschrift voor Psychiatrie

JF - Tijdschrift voor Psychiatrie

IS - 11

ER -