TY - JOUR
T1 - Family history and risk of bladder cancer
T2 - an analysis accounting for first- and second-degree relatives
AU - Yu, Evan Yi-Wen
AU - Stern, Mariana C
AU - Jiang, Xuejuan
AU - Tang, Li
AU - van den Brandt, Piet A
AU - Lu, Chih-Ming
AU - Karagas, Margaret R
AU - La Vecchia, Carlo
AU - Bosetti, Cristina
AU - Polesel, Jerry
AU - Golka, Klaus
AU - Zhang, Zuo-Feng
AU - Villeneuve, Paul
AU - Zeegers, Maurice P
AU - Wesselius, Anke
N1 - Copyright ©2022, American Association for Cancer Research.
PY - 2022/5
Y1 - 2022/5
N2 - Although evidence suggests that a positive family history of bladder cancer in first-degree relatives is an important risk factor for bladder cancer occurrence, results remain unclear. The influence of family history of non-bladder cancers and more distant relatives on bladder cancer risk is inconsistent. This research therefore, aims to increase the understanding of the association between family history and bladder cancer risk based on worldwide case-control studies. In total 4,327 cases and 8,948 non-cases were included. Pooled odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models, adjusted by age, sex, ethnicity, smoking status, and smoking pack-years. The results show bladder cancer risk increased by having a first- or second-degree relative affected with bladder cancer (OR 2.72, 95%CI 1.55-4.77 and OR 1.71, 95%CI 1.22-2.40, respectively), and non-urologic cancers (OR 1.61, 95%CI 1.19-2.18). Moreover, bladder cancer risk increased by number of cancers affected first-degree relatives (for 1 and >1 first-degree relatives: OR 1.42, 95% CI 1.02-2.04; OR 2.67, 95% CI 1.84-3.86, respectively). Our findings highlight an increased bladder cancer risk for a positive bladder cancer family history in first- and second-degree relatives, and indicate a possible greater effect for an increment of numbers of affected relatives.
AB - Although evidence suggests that a positive family history of bladder cancer in first-degree relatives is an important risk factor for bladder cancer occurrence, results remain unclear. The influence of family history of non-bladder cancers and more distant relatives on bladder cancer risk is inconsistent. This research therefore, aims to increase the understanding of the association between family history and bladder cancer risk based on worldwide case-control studies. In total 4,327 cases and 8,948 non-cases were included. Pooled odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models, adjusted by age, sex, ethnicity, smoking status, and smoking pack-years. The results show bladder cancer risk increased by having a first- or second-degree relative affected with bladder cancer (OR 2.72, 95%CI 1.55-4.77 and OR 1.71, 95%CI 1.22-2.40, respectively), and non-urologic cancers (OR 1.61, 95%CI 1.19-2.18). Moreover, bladder cancer risk increased by number of cancers affected first-degree relatives (for 1 and >1 first-degree relatives: OR 1.42, 95% CI 1.02-2.04; OR 2.67, 95% CI 1.84-3.86, respectively). Our findings highlight an increased bladder cancer risk for a positive bladder cancer family history in first- and second-degree relatives, and indicate a possible greater effect for an increment of numbers of affected relatives.
KW - ASSOCIATION
KW - CONSUMPTION
KW - METAANALYSIS
KW - MORTALITY
KW - NAT2 SLOW ACETYLATION
KW - POLYMORPHISMS
KW - POOLED ANALYSIS
KW - TOBACCO SMOKING
KW - TRANSITIONAL-CELL CARCINOMA
KW - URINARY-BLADDER
U2 - 10.1158/1940-6207.CAPR-21-0490
DO - 10.1158/1940-6207.CAPR-21-0490
M3 - Article
C2 - 35027464
SN - 1940-6207
VL - 15
SP - 319
EP - 326
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 5
ER -