Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings

M. A. Islam; M. F. H. Khan; P. J. Quee; H. Snieder; E. R. van den Heuvel; R. Bruggeman; B. Z. Alizadeh; A. A. Bartels-Velthuis; N. J. van Beveren; W. Cahn; L. de Haan; P. Delespaul; C. J. Meijer; I. Myin-Germeys; R. S. Kahn; F. Schirmbeck; C. J. P. Simons; N. E. van Haren; J. van Os; R. van Winkel; GRP Investigators

doi:10.1016/j.eurpsy.2017.05.001

Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings

M. A. Islam^*, M. F. H. Khan, P. J. Quee, H. Snieder, E. R. van den Heuvel, R. Bruggeman, B. Z. Alizadeh, A. A. Bartels-Velthuis, N. J. van Beveren, W. Cahn, L. de Haan, P. Delespaul, C. J. Meijer, I. Myin-Germeys, R. S. Kahn, F. Schirmbeck, C. J. P. Simons, N. E. van Haren, J. van Os, R. van WinkelGRP Investigators

^*Corresponding author for this work

MHeNs - Mental Health

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Web of Science)

Abstract

Background: Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.

Methods: We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity.

Results: Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79-2.69, P <0.001) and to controls (3.05, 2.35-3.96, P <0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05-1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups.

Conclusion: Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity. (C) 2017 Elsevier Masson SAS. All rights reserved.

Original language	English
Pages (from-to)	81-89
Number of pages	9
Journal	European Psychiatry
Volume	45
DOIs	https://doi.org/10.1016/j.eurpsy.2017.05.001
Publication status	Published - Sep 2017

Keywords

Familial liability
Multimorbidity
Physical health
Psychosis
Schizophrenia
MAJOR DEPRESSIVE DISORDER
SEVERE MENTAL-ILLNESS
BIPOLAR DISORDER
GENERAL-PRACTICE
HEALTH-CARE
PHYSICAL ILLNESS
CHRONIC DISEASE
CO-MORBIDITY
SCHIZOPHRENIA
PREVALENCE

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10.1016/j.eurpsy.2017.05.001

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Islam, M. A., Khan, M. F. H., Quee, P. J., Snieder, H., van den Heuvel, E. R., Bruggeman, R., Alizadeh, B. Z., Bartels-Velthuis, A. A., van Beveren, N. J., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Haren, N. E., van Os, J., ... GRP Investigators (2017). Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings. European Psychiatry, 45, 81-89. https://doi.org/10.1016/j.eurpsy.2017.05.001

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title = "Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings",

abstract = "Background: Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.Methods: We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity.Results: Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79-2.69, P <0.001) and to controls (3.05, 2.35-3.96, P <0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05-1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups.Conclusion: Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity. (C) 2017 Elsevier Masson SAS. All rights reserved.",

keywords = "Familial liability, Multimorbidity, Physical health, Psychosis, Schizophrenia, MAJOR DEPRESSIVE DISORDER, SEVERE MENTAL-ILLNESS, BIPOLAR DISORDER, GENERAL-PRACTICE, HEALTH-CARE, PHYSICAL ILLNESS, CHRONIC DISEASE, CO-MORBIDITY, SCHIZOPHRENIA, PREVALENCE",

author = "Islam, {M. A.} and Khan, {M. F. H.} and Quee, {P. J.} and H. Snieder and {van den Heuvel}, {E. R.} and R. Bruggeman and Alizadeh, {B. Z.} and Bartels-Velthuis, {A. A.} and {van Beveren}, {N. J.} and W. Cahn and {de Haan}, L. and P. Delespaul and Meijer, {C. J.} and I. Myin-Germeys and Kahn, {R. S.} and F. Schirmbeck and Simons, {C. J. P.} and {van Haren}, {N. E.} and {van Os}, J. and {van Winkel}, R. and {GRP Investigators}",

year = "2017",

month = sep,

doi = "10.1016/j.eurpsy.2017.05.001",

language = "English",

volume = "45",

pages = "81--89",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier France-{\'E}ditions Scientifiques et Medicales Elsevier",

}

Islam, MA, Khan, MFH, Quee, PJ, Snieder, H, van den Heuvel, ER, Bruggeman, R, Alizadeh, BZ, Bartels-Velthuis, AA, van Beveren, NJ, Cahn, W, de Haan, L, Delespaul, P, Meijer, CJ, Myin-Germeys, I, Kahn, RS, Schirmbeck, F, Simons, CJP, van Haren, NE, van Os, J, van Winkel, R & GRP Investigators 2017, 'Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings', European Psychiatry, vol. 45, pp. 81-89. https://doi.org/10.1016/j.eurpsy.2017.05.001

TY - JOUR

T1 - Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings

AU - Islam, M. A.

AU - Khan, M. F. H.

AU - Quee, P. J.

AU - Snieder, H.

AU - van den Heuvel, E. R.

AU - Bruggeman, R.

AU - Alizadeh, B. Z.

AU - Bartels-Velthuis, A. A.

AU - van Beveren, N. J.

AU - Cahn, W.

AU - de Haan, L.

AU - Delespaul, P.

AU - Meijer, C. J.

AU - Myin-Germeys, I.

AU - Kahn, R. S.

AU - Schirmbeck, F.

AU - Simons, C. J. P.

AU - van Haren, N. E.

AU - van Os, J.

AU - van Winkel, R.

AU - GRP Investigators

PY - 2017/9

Y1 - 2017/9

N2 - Background: Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.Methods: We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity.Results: Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79-2.69, P <0.001) and to controls (3.05, 2.35-3.96, P <0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05-1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups.Conclusion: Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity. (C) 2017 Elsevier Masson SAS. All rights reserved.

AB - Background: Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity.Methods: We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity.Results: Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79-2.69, P <0.001) and to controls (3.05, 2.35-3.96, P <0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05-1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups.Conclusion: Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity. (C) 2017 Elsevier Masson SAS. All rights reserved.

KW - Familial liability

KW - Multimorbidity

KW - Physical health

KW - Psychosis

KW - Schizophrenia

KW - MAJOR DEPRESSIVE DISORDER

KW - SEVERE MENTAL-ILLNESS

KW - BIPOLAR DISORDER

KW - GENERAL-PRACTICE

KW - HEALTH-CARE

KW - PHYSICAL ILLNESS

KW - CHRONIC DISEASE

KW - CO-MORBIDITY

KW - SCHIZOPHRENIA

KW - PREVALENCE

U2 - 10.1016/j.eurpsy.2017.05.001

DO - 10.1016/j.eurpsy.2017.05.001

M3 - Article

C2 - 28750277

VL - 45

SP - 81

EP - 89

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

ER -