FAIR and bias-free network modules for mechanism-based disease redefinitions

Research output: ThesisDoctoral ThesisInternal

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Abstract

Even though chronic diseases are the cause of 60% of all deaths around the world, the underlying causes for most of them are not fully understood. Hence, diseases are defined based on organs and symptoms, and therapies largely focus on mitigating symptoms rather than cure. This is also reflected in the most commonly used disease classifications. The complex nature of diseases, however, can be better defined in terms of networks of molecular interactions. This research applies the approaches of network medicine – a field that uses network science for identifying and treating diseases – to multiple diseases with highly unmet medical need such as stroke and hypertension. The results show the success of this approach to analyse complex disease networks and predict drug targets for different conditions, which are validated through preclinical experiments and are currently in human clinical trials.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schmidt, Harald, Supervisor
  • Dumontier, Michel, Supervisor
Award date7 Jul 2021
Place of PublicationMaastricht
Publisher
Print ISBNs9789464213959
DOIs
Publication statusPublished - 2021

Keywords

  • network medicine
  • disease modules
  • mechanistic definitions
  • reproducibility

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