Failures (with some successes) of assisted reproduction and gamete donation programs

D. T. Baird; S. Bhattacharya; P. Devroey; K. Diedrich; J. L. H. Evers; B. C. J. M. Fauser; P. Jouannet; A. Pellicer; E. Walters; P. G. Crosignani; L. Fraser; J. P. M. Geraedts; L. Gianaroli; A. Glasier; I. Liebaers; A. Sunde; J. S. Tapanainen; B. Tarlatzis; A. Van Steirteghem; A. Veiga

doi:10.1093/humupd/dmt007

Failures (with some successes) of assisted reproduction and gamete donation programs

D. T. Baird, S. Bhattacharya, P. Devroey, K. Diedrich, J. L. H. Evers, B. C. J. M. Fauser, P. Jouannet, A. Pellicer, E. Walters, P. G. Crosignani^*, L. Fraser, J. P. M. Geraedts, L. Gianaroli, A. Glasier, I. Liebaers, A. Sunde, J. S. Tapanainen, B. Tarlatzis, A. Van Steirteghem, A. Veiga

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully. Crude overall pregnancy rates of 5065 per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first. IVF only accounts for about 20 of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success. Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80 may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.

Original language	English
Pages (from-to)	354-365
Journal	Human Reproduction Update
Volume	19
Issue number	4
DOIs	https://doi.org/10.1093/humupd/dmt007
Publication status	Published - 2013

Keywords

assisted reproduction technology
ICSI
intrauterine insemination
IVF
oocyte donation

Access to Document

10.1093/humupd/dmt007

Cite this

Baird, D. T., Bhattacharya, S., Devroey, P., Diedrich, K., Evers, J. L. H., Fauser, B. C. J. M., Jouannet, P., Pellicer, A., Walters, E., Crosignani, P. G., Fraser, L., Geraedts, J. P. M., Gianaroli, L., Glasier, A., Liebaers, I., Sunde, A., Tapanainen, J. S., Tarlatzis, B., Van Steirteghem, A., & Veiga, A. (2013). Failures (with some successes) of assisted reproduction and gamete donation programs. Human Reproduction Update, 19(4), 354-365. https://doi.org/10.1093/humupd/dmt007

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title = "Failures (with some successes) of assisted reproduction and gamete donation programs",

abstract = "Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully. Crude overall pregnancy rates of 5065 per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first. IVF only accounts for about 20 of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success. Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80 may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.",

keywords = "assisted reproduction technology, ICSI, intrauterine insemination, IVF, oocyte donation",

author = "Baird, {D. T.} and S. Bhattacharya and P. Devroey and K. Diedrich and Evers, {J. L. H.} and Fauser, {B. C. J. M.} and P. Jouannet and A. Pellicer and E. Walters and Crosignani, {P. G.} and L. Fraser and Geraedts, {J. P. M.} and L. Gianaroli and A. Glasier and I. Liebaers and A. Sunde and Tapanainen, {J. S.} and B. Tarlatzis and {Van Steirteghem}, A. and A. Veiga",

year = "2013",

doi = "10.1093/humupd/dmt007",

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volume = "19",

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journal = "Human Reproduction Update",

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Baird, DT, Bhattacharya, S, Devroey, P, Diedrich, K, Evers, JLH, Fauser, BCJM, Jouannet, P, Pellicer, A, Walters, E, Crosignani, PG, Fraser, L, Geraedts, JPM, Gianaroli, L, Glasier, A, Liebaers, I, Sunde, A, Tapanainen, JS, Tarlatzis, B, Van Steirteghem, A & Veiga, A 2013, 'Failures (with some successes) of assisted reproduction and gamete donation programs', Human Reproduction Update, vol. 19, no. 4, pp. 354-365. https://doi.org/10.1093/humupd/dmt007

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T1 - Failures (with some successes) of assisted reproduction and gamete donation programs

AU - Baird, D. T.

AU - Bhattacharya, S.

AU - Devroey, P.

AU - Diedrich, K.

AU - Evers, J. L. H.

AU - Fauser, B. C. J. M.

AU - Jouannet, P.

AU - Pellicer, A.

AU - Walters, E.

AU - Crosignani, P. G.

AU - Fraser, L.

AU - Geraedts, J. P. M.

AU - Gianaroli, L.

AU - Glasier, A.

AU - Liebaers, I.

AU - Sunde, A.

AU - Tapanainen, J. S.

AU - Tarlatzis, B.

AU - Van Steirteghem, A.

AU - Veiga, A.

PY - 2013

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AB - Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully. Crude overall pregnancy rates of 5065 per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first. IVF only accounts for about 20 of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success. Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80 may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.

KW - assisted reproduction technology

KW - ICSI

KW - intrauterine insemination

KW - IVF

KW - oocyte donation

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DO - 10.1093/humupd/dmt007

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VL - 19

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JO - Human Reproduction Update

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