Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P. Nieboer; E.E. de Vries; N.H. Mulder; S. Rodenhuis; M. Bontenbal; E. van der Wall; Q.G. van Hoesel; W.M. Smit; P.S.G.J. Hupperets; E.E. Voest; M.A. Nooij; H.M. Boezen; W. de Graaf

doi:10.1038/bmt.2008.195

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P. Nieboer, E.E. de Vries, N.H. Mulder, S. Rodenhuis, M. Bontenbal, E. van der Wall, Q.G. van Hoesel, W.M. Smit, P.S.G.J. Hupperets, E.E. Voest, M.A. Nooij, H.M. Boezen, W. de Graaf^*

^*Corresponding author for this work

GROW School for Oncology and Developmental Biology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia > 10 days (P = 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P =

Original language	English
Pages (from-to)	475-481
Journal	Bone Marrow Transplantation
Volume	42
Issue number	7
DOIs	https://doi.org/10.1038/bmt.2008.195
Publication status	Published - 1 Jan 2008

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10.1038/bmt.2008.195

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Nieboer, P., de Vries, E. E., Mulder, N. H., Rodenhuis, S., Bontenbal, M., van der Wall, E., van Hoesel, Q. G., Smit, W. M., Hupperets, P. S. G. J., Voest, E. E., Nooij, M. A., Boezen, H. M., & de Graaf, W. (2008). Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. Bone Marrow Transplantation, 42(7), 475-481. https://doi.org/10.1038/bmt.2008.195

Nieboer, P. ; de Vries, E.E. ; Mulder, N.H. ; Rodenhuis, S. ; Bontenbal, M. ; van der Wall, E. ; van Hoesel, Q.G. ; Smit, W.M. ; Hupperets, P.S.G.J. ; Voest, E.E. ; Nooij, M.A. ; Boezen, H.M. ; de Graaf, W. / Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. In: Bone Marrow Transplantation. 2008 ; Vol. 42, No. 7. pp. 475-481.

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title = "Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients",

abstract = "Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia > 10 days (P = 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P = ",

author = "P. Nieboer and {de Vries}, E.E. and N.H. Mulder and S. Rodenhuis and M. Bontenbal and {van der Wall}, E. and {van Hoesel}, Q.G. and W.M. Smit and P.S.G.J. Hupperets and E.E. Voest and M.A. Nooij and H.M. Boezen and {de Graaf}, W.",

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Nieboer, P, de Vries, EE, Mulder, NH, Rodenhuis, S, Bontenbal, M, van der Wall, E, van Hoesel, QG, Smit, WM, Hupperets, PSGJ, Voest, EE, Nooij, MA, Boezen, HM & de Graaf, W 2008, 'Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients', Bone Marrow Transplantation, vol. 42, no. 7, pp. 475-481. https://doi.org/10.1038/bmt.2008.195

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. / Nieboer, P.; de Vries, E.E.; Mulder, N.H.; Rodenhuis, S.; Bontenbal, M.; van der Wall, E.; van Hoesel, Q.G.; Smit, W.M.; Hupperets, P.S.G.J.; Voest, E.E.; Nooij, M.A.; Boezen, H.M.; de Graaf, W.

In: Bone Marrow Transplantation, Vol. 42, No. 7, 01.01.2008, p. 475-481.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - de Vries, E.E.

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AU - Rodenhuis, S.

AU - Bontenbal, M.

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AU - van Hoesel, Q.G.

AU - Smit, W.M.

AU - Hupperets, P.S.G.J.

AU - Voest, E.E.

AU - Nooij, M.A.

AU - Boezen, H.M.

AU - de Graaf, W.

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