Abstract
Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia > 10 days (P = 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P =
Original language | English |
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Pages (from-to) | 475-481 |
Journal | Bone Marrow Transplantation |
Volume | 42 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jan 2008 |