Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P. Nieboer, E.E. de Vries, N.H. Mulder, S. Rodenhuis, M. Bontenbal, E. van der Wall, Q.G. van Hoesel, W.M. Smit, P.S.G.J. Hupperets, E.E. Voest, M.A. Nooij, H.M. Boezen, W. de Graaf

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Abstract

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia > 10 days (P = 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P =
Original languageEnglish
Pages (from-to)475-481
JournalBone Marrow Transplantation
Volume42
Issue number7
DOIs
Publication statusPublished - 1 Jan 2008

Cite this

Nieboer, P., de Vries, E. E., Mulder, N. H., Rodenhuis, S., Bontenbal, M., van der Wall, E., van Hoesel, Q. G., Smit, W. M., Hupperets, P. S. G. J., Voest, E. E., Nooij, M. A., Boezen, H. M., & de Graaf, W. (2008). Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. Bone Marrow Transplantation, 42(7), 475-481. https://doi.org/10.1038/bmt.2008.195