Factors associated with poor outcome in fetuses prenatally diagnosed with sacrococcygeal teratoma

L.J. van Heurn*, A.B.C. Coumans, J.P.M. Derikx, M.N. Bekker, K.M. Bilardo, L.K. Duin, M.F.C.M. Knapen, E. Pajkrt, E. Sikkel, L.W.E. van Heurn*, D. Oepkes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aim of the study Outcome of fetuses, prenatally diagnosed with sacrococcygeal teratoma (SCT), is still poorly documented. This study assesses the incidence and prenatal predictors of outcome in all fetuses prenatally diagnosed with SCT. Methods This is a retrospective study on all fetuses prenatally diagnosed with SCT from 1998 to 2018 in the Netherlands. Poor outcome was defined as terminations of pregnancy (TOP) because of expected unfavorable outcome, intrauterine fetal death, or early neonatal death. Potential risk factors for poor outcome were analyzed. Main results Eighty-four fetuses were included. Sixteen (19.0%) TOPs were excluded from statistical analysis. Eleven of the remaining 68 fetuses had poor outcome. Overall mortality was 32.1%, with a mortality excluding TOPs of 13.1%. Thirteen fetal interventions were performed in 11 (13.1%) fetuses. Potential risk factors for poor outcome were the presence of fetal hydrops (OR: 21.0, CI: 2.6-275.1, p = 0.012) and cardiomegaly (OR: 10.3, CI: 1.9-55.8, p = 0.011). Conclusions The overall mortality of fetuses prenatally diagnosed with SCTs including tTOP was 32.1%. This high mortality rate was mainly due to termination of pregnancy. Mortality excluding TOP was 13.1%. Potential risk factors for poor outcome were fetal hydrops and cardiomegaly.
Original languageEnglish
Pages (from-to)1430-1438
Number of pages9
JournalPrenatal Diagnosis
Volume41
Issue number11
Early online date5 Aug 2021
DOIs
Publication statusPublished - Oct 2021

Keywords

  • FETAL WEIGHT RATIO
  • 25-YEAR EXPERIENCE
  • TUMOR VOLUME
  • PROGNOSIS
  • CHILDREN
  • PREVALENCE
  • RECURRENCE
  • MANAGEMENT
  • INFANTS
  • GROWTH

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