TY - JOUR
T1 - Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
AU - Mahmoodi, Bakhtawar K.
AU - Eriksson, Niclas
AU - Vos, Gerrit J. A.
AU - Meijer, Karina
AU - Siegbahn, Agneta
AU - James, Stefan
AU - Wallentin, Lars
AU - ten Berg, Jurrien M.
N1 - Funding Information:
The authors would like to express their immense gratitude to all patients who participated in each of the individual studies as well as the many employees who helped with recruitment, collection, curation, management, and processing of the samples and data. Author contributions: Dr Mahmoodi developed the analysis script and performed the analysis in the POPular Genetics trial. Dr Eriksson prepared the data sets and applied the analysis script to the PLATO trial. Dr Mahmoodi drafted the manuscript. Drs Wallentin and ten Berg supervised the preparation of the manuscript. All authors took part in the interpretation of the data, and all authors provided critical revisions of the manuscript for important intellectual content.Sources of Funding The PLATO trial was funded by AstraZeneca. Support for the analysis and the interpretation of the PLATO trial results was provided through funds to the Uppsala Clinical Research Center and Duke Clinical Research Institute as part of the Clinical Study Agreement. The POPular Genetics trial was funded by the Netherlands Organization for Health Research and Development.
Funding Information:
The PLATO trial was funded by AstraZeneca. Support for the analysis and the interpretation of the PLATO trial results was provided through funds to the Uppsala Clinical Research Center and Duke Clinical Research Institute as part of the Clinical Study Agreement. The POPular Genetics trial was funded by the Netherlands Organization for Health Research and Development.
Publisher Copyright:
© 2021 The Authors.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - BACKGROUND: The prothrombotic defect factor V Leiden (FVL) may confer higher risk of ST-segment-elevation myocardial infarction (STEMI), compared with non-ST-segment-elevation acute coronary syndrome, and may be associated with more myocardial necrosis caused by higher thrombotic burden.METHODS AND RESULTS: Patients without history of cardiovascular disease were selected from 2 clinical trials conducted in patients with acute coronary syndrome. FVL was defined as G-to-A substitution at nucleotide 1691 in the factor V (factor V R506Q) gene. Odds ratios were calculated for the association of FVL with STEMI adjusted for age and sex in the overall population and in the subgroups including sex, age (>= 70 versusCONCLUSIONS: In a general population with acute coronary syndrome, FVL did not discriminate between a STEMI or non-ST-segment-elevation acute coronary syndrome presentation and was unrelated to peak cardiac necrosis markers in patients with STEMI.
AB - BACKGROUND: The prothrombotic defect factor V Leiden (FVL) may confer higher risk of ST-segment-elevation myocardial infarction (STEMI), compared with non-ST-segment-elevation acute coronary syndrome, and may be associated with more myocardial necrosis caused by higher thrombotic burden.METHODS AND RESULTS: Patients without history of cardiovascular disease were selected from 2 clinical trials conducted in patients with acute coronary syndrome. FVL was defined as G-to-A substitution at nucleotide 1691 in the factor V (factor V R506Q) gene. Odds ratios were calculated for the association of FVL with STEMI adjusted for age and sex in the overall population and in the subgroups including sex, age (>= 70 versusCONCLUSIONS: In a general population with acute coronary syndrome, FVL did not discriminate between a STEMI or non-ST-segment-elevation acute coronary syndrome presentation and was unrelated to peak cardiac necrosis markers in patients with STEMI.
KW - cardiovascular disease
KW - cardiovascular disease risk factors
KW - coagulation/thrombosis
KW - factor V Leiden
KW - genetic polymorphism
KW - METAANALYSIS
KW - INFARCTION
KW - DISEASE
U2 - 10.1161/JAHA.120.020025
DO - 10.1161/JAHA.120.020025
M3 - Article
C2 - 33998271
SN - 2047-9980
VL - 10
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 11
M1 - 020025
ER -