TY - JOUR
T1 - Clustering of Cardiac Transcriptome Profiles Reveals Unique Subgroups of Dilated Cardiomyopathy Patients
AU - Verdonschot, Job A. J.
AU - Wang, Ping
AU - Derks, Kasper W. J.
AU - Adriaens, Michiel E.
AU - Stroeks, Sophie L. V. M.
AU - Henkens, Michiel T. H. M.
AU - Raafs, Anne G.
AU - Sikking, Maurits
AU - de Koning, Bart
AU - van den Wijngaard, Arthur
AU - Krapels, Ingrid P. C.
AU - Nabben, Miranda
AU - Brunner, Han G.
AU - Heymans, Stephane R. B.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Dilated cardiomyopathy is a heterogeneous disease characterized by multiple genetic and environmental etiol-ogies. The majority of patients are treated the same despite these differences. The cardiac transcriptome provides information on the patient's pathophysiology, which allows targeted therapy. Using clustering techniques on data from the genotype, phenotype, and cardiac transcriptome of patients with early-and end-stage dilated cardiomyopathy, more homogeneous patient subgroups are identified based on shared underlying pathophysi-ology. Distinct patient subgroups are identified based on differences in protein quality control, cardiac meta-bolism, cardiomyocyte function, and inflammatory pathways. The identified pathways have the potential to guide future treatment and individualize patient care. (J Am Coll Cardiol Basic Trans Science 2023;8:406-418) (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
AB - Dilated cardiomyopathy is a heterogeneous disease characterized by multiple genetic and environmental etiol-ogies. The majority of patients are treated the same despite these differences. The cardiac transcriptome provides information on the patient's pathophysiology, which allows targeted therapy. Using clustering techniques on data from the genotype, phenotype, and cardiac transcriptome of patients with early-and end-stage dilated cardiomyopathy, more homogeneous patient subgroups are identified based on shared underlying pathophysi-ology. Distinct patient subgroups are identified based on differences in protein quality control, cardiac meta-bolism, cardiomyocyte function, and inflammatory pathways. The identified pathways have the potential to guide future treatment and individualize patient care. (J Am Coll Cardiol Basic Trans Science 2023;8:406-418) (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
KW - clustering
KW - dilated cardiomyopathy
KW - genetics
KW - transcriptomics
KW - TITIN
KW - DIAGNOSIS
KW - DEFINITION
KW - MUTATIONS
KW - HEALTH
U2 - 10.1016/j.jacbts.2022.10.010
DO - 10.1016/j.jacbts.2022.10.010
M3 - Article
C2 - 37138803
SN - 2452-302X
VL - 8
SP - 406
EP - 418
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 4
ER -