Extracellular Vesicles in CNS Developmental Disorders

Ana Rita Gomes, Nasim Bahram Sangani, Tiago G. Fernandes, M. Margarida Diogo, Leopold M. G. Curfs, Chris P. Reutelingsperger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Web of Science)

Abstract

The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.

Original languageEnglish
Article number9428
Number of pages20
JournalInternational journal of molecular sciences
Volume21
Issue number24
DOIs
Publication statusPublished - Dec 2020

Keywords

  • neurodevelopmental disorders
  • extracellular vesicles
  • exosomes
  • microvesicles
  • CNS
  • neurons
  • astrocytes
  • glia
  • EXOSOME-MEDIATED TRANSFER
  • AMYLOID-BETA
  • RETT-SYNDROME
  • ALZHEIMERS-DISEASE
  • NEURAL CELLS
  • BRAIN
  • BDNF
  • MICROVESICLES
  • SECRETION
  • MICROGLIA

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