Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Annemiek Dickhout, Rory R. Koenen*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

73 Citations (Web of Science)
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Abstract

The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.
Original languageEnglish
Article number113
Number of pages9
JournalFrontiers in cardiovascular medicine
Volume5
DOIs
Publication statusPublished - 22 Aug 2018

Keywords

  • microparticle
  • atherosclerosis
  • vascular remodeling
  • diagnostic
  • platelet
  • endothelial cell
  • monocyte
  • CIRCULATING ENDOTHELIAL MICROPARTICLES
  • PLATELET-DERIVED MICROPARTICLES
  • NANOPARTICLE TRACKING ANALYSIS
  • MYOCARDIAL-INFARCTION PATIENTS
  • ACUTE CORONARY SYNDROMES
  • FLOW-CYTOMETRY
  • TISSUE FACTOR
  • SUBCLINICAL ATHEROSCLEROSIS
  • VENOUS THROMBOEMBOLISM
  • MATRIX VESICLES

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