Abstract
ObjectiveThis study aims to evaluate whether extracapsular extension (ECE) in the sentinel lymph node (SLN) is associated with involvement of 4 lymph node metastases at completion axillary lymph node dissection (ALND) and the effect on 5-year disease-free survival (DFS) and 10-year overall survival (OS).Summary background dataECE in a SLN is usually a contraindication for omitting completion ALND in cT1-2N0 breast cancer patients treated with breast-conserving therapy and 1-2 positive SLN(s).MethodsAll cT1-2N0 breast cancer patients with 1-3 positive SLN(s) who underwent ALND between 2005 and 2008 were selected from the Netherlands Cancer Registry. Logistic regression analysis was used to determine the association between ECE and 4 lymph node metastases. Five-year DFS and 10-year OS were analyzed using Kaplan-Meier survival analysis. Cox regression analysis was performed to correct for other prognostic factors.ResultsA total of 3502 patients were included. Information on ECE was available for 2111 (60.3%) patients, consisting of 741 (35.1%) patients with and 1370 (64.9%) without ECE. The incidence of 4 lymph node metastases was 116 (15.7%) in the ECE group vs. 80 (5.8%) in the group without ECE (p
Original language | English |
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Pages (from-to) | 711-718 |
Number of pages | 8 |
Journal | Breast Cancer Research and Treatment |
Volume | 174 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 2019 |
Keywords
- Breast cancer
- Sentinel lymph node
- Axillary lymph node dissection
- Extracapsular extension
- Disease-free survival
- Overall survival
- AXILLARY DISSECTION
- METASTASIS
- INVASION
- TRIAL
- PREDICTOR
- WOMEN